ID   WDY_DROWI               Reviewed;        1089 AA.
AC   B7FF09; B4N7A0;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=WD repeat-containing protein on Y chromosome {ECO:0000303|PubMed:19011613, ECO:0000312|EMBL:DAA06443.1};
DE            Short=WD40 Y {ECO:0000303|PubMed:19011613};
GN   Name=WDY {ECO:0000312|EMBL:DAA06443.1}; ORFNames=GK21064;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1] {ECO:0000312|EMBL:EDW80241.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24 {ECO:0000269|PubMed:17994087};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:DAA06443.1}
RP   IDENTIFICATION.
RX   PubMed=19011613; DOI=10.1038/nature07463;
RA   Koerich L.B., Wang X., Clark A.G., Carvalho A.B.;
RT   "Low conservation of gene content in the Drosophila Y chromosome.";
RL   Nature 456:949-951(2008).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=B {ECO:0000269|PubMed:19011613};
CC         IsoId=B7FF09-1; Sequence=Displayed;
CC       Name=A {ECO:0000269|PubMed:17994087};
CC         IsoId=B7FF09-2; Sequence=VSP_053099, VSP_053100;
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DR   EMBL; CH964182; EDW80241.1; -; Genomic_DNA.
DR   EMBL; BK006446; DAA06443.1; -; Genomic_DNA.
DR   RefSeq; XP_002069255.2; XM_002069219.2.
DR   AlphaFoldDB; B7FF09; -.
DR   InParanoid; B7FF09; -.
DR   OMA; YIYAWSL; -.
DR   ChiTaRS; WDY; fly.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR011044; Quino_amine_DH_bsu.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF50969; SSF50969; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   4: Predicted;
KW   Alternative splicing; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1089
FT                   /note="WD repeat-containing protein on Y chromosome"
FT                   /id="PRO_0000378999"
FT   REPEAT          155..199
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          207..249
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          329..368
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          372..411
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          462..501
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          514..553
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          601..641
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          767..806
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          850..889
FT                   /note="WD 9"
FT                   /evidence="ECO:0000255"
FT   REGION          661..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1049..1089
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1053..1079
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         204..205
FT                   /note="SN -> IHLKMPTWILAVQALSDVSVVCTSSTERELRFHETIASTFSLRMVI
FT                   RS (in isoform A)"
FT                   /evidence="ECO:0000303|PubMed:17994087"
FT                   /id="VSP_053099"
FT   VAR_SEQ         803..869
FT                   /note="Missing (in isoform A)"
FT                   /evidence="ECO:0000303|PubMed:17994087"
FT                   /id="VSP_053100"
SQ   SEQUENCE   1089 AA;  123962 MW;  DFE8DE69A6BD2399 CRC64;
     MSAILNASVD SNTNIEYQTI SSTQSQISEE QSERLHDRIS KEQLEKLHEA FKAYPDQQLG
     VEELREVLEE VDIVFNDAVY TRLFLKINQN HDFRVDWNEF VSYLIFGFQE EDPSSQKESL
     ILPISVPPVV RKSEHRSAVC CLALLKVKSD QAPLEEVAET SNFSFGGEDS PEASGMWVTA
     SHEGMMKFWS SHMEPIRTAS SESSNLPHAV YVMSYAFYNN GKVHSKLILG DYGGNVRILS
     YSPHLRGPFQ AKPGAALIEV VWSDVLKGKI PLLIPKEYIN LHSELISCVY YSLHMNALFA
     SAEYRNTKKY RGRCPGIIMV SYGDKSNFRI PLGVTTFFVA ESHNIVVTGG PDTFVRIWDV
     YIPTEPSAIL TGHNGGIVMV FVQPEENKVY SVDYQKIIKV WNLQEHTLLQ TYGDLVRLIH
     HTETDLTYYY HSHLRELIVA GRKLISIKCC PRVRVDLTDG NTHAAPVSVV LYNRLFRNIV
     TCGLDSYIIV WDPWTGRRKI IMKSCHTKMI YGETIDIEIT AACFDPLEQF LLTGARDGSL
     KIWNYNNAVV IRNMSIQPDQ EVTAVIWVVE RILAMGWDRQ VTEFNDVEGR EYGDPKKWPK
     FHTDDITCGD VKLGEGVVTA TYSGEIIFWK LETGQPYRRY SVMEPKRFIE LKLSDEEKQM
     KRSKRWASRA PHSGSHMMSH TGSHMGSNVD QMSGSRSRGL AILQGQEEIR EYGVNVPISV
     QAVLFLQNRP QTLHHGSVFI SLDTGIIQVY SHHQRGGYMN EFLAVHKTGD CVLTMATDRK
     NRFLFTGTAF GYIKVWYIVN YCIPEAEKIH VCMPRLRLDF IFLRKETFLT RAKRVVRNQA
     EPLLVSSYKG HLKAINSISF INLPKIIITG SHDYSCRLWT QGGRYLGTLG SVLPWTKLSP
     FERAGDDTHV YRLPPDIKKV ASSTTLKVIS GLQVDRPMKR PDKAKTEEKE EDTAQALETN
     DLKKLFDRPL KDPILGKHFQ LPGRSALDQR IDLDTTQSYI PVYTNLKVHP SEELERLPTP
     AVISRVQAEN YLHQYLPVEG KVDLNDSALN IKLPSRRRSD RTNDPRNMRT AKTRGDMGLG
     HRSSHTSQN