ID   WDY_DROYA               Reviewed;        1068 AA.
AC   B7FF12; B0FXQ6;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=WD repeat-containing protein on Y chromosome {ECO:0000303|PubMed:19011613, ECO:0000312|EMBL:DAA06446.1};
DE            Short=WD40 Y {ECO:0000303|PubMed:19011613};
GN   Name=WDY {ECO:0000312|EMBL:DAA06446.1};
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000269|PubMed:17994087};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:DAA06446.1}
RP   IDENTIFICATION, AND NUCLEOTIDE SEQUENCE [MRNA] OF 79-1068.
RX   PubMed=19011613; DOI=10.1038/nature07463;
RA   Koerich L.B., Wang X., Clark A.G., Carvalho A.B.;
RT   "Low conservation of gene content in the Drosophila Y chromosome.";
RL   Nature 456:949-951(2008).
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DR   EMBL; BK006450; DAA06446.1; -; Genomic_DNA.
DR   EMBL; AAEU02004787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEU02008933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEU02010905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EU362856; ABY59795.1; -; mRNA.
DR   AlphaFoldDB; B7FF12; -.
DR   PRIDE; B7FF12; -.
DR   EnsemblMetazoa; FBtr0396545; FBpp0355729; FBgn0276259.
DR   EnsemblMetazoa; FBtr0406073; FBpp0364669; FBgn0276869.
DR   OrthoDB; 1225585at2759; -.
DR   ChiTaRS; WDY; fly.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Repeat; WD repeat.
FT   CHAIN           1..1068
FT                   /note="WD repeat-containing protein on Y chromosome"
FT                   /id="PRO_0000377425"
FT   REPEAT          155..199
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          201..242
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          322..361
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          365..404
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          455..494
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          507..546
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          594..634
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          746..785
FT                   /note="WD 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          829..868
FT                   /note="WD 9"
FT                   /evidence="ECO:0000255"
FT   REGION          657..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1026..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1033..1052
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1068 AA;  121826 MW;  5E2B32D1138566EB CRC64;
     MSVILNASVN TKSAVEYRTI SSTQSHLAEE QSERLHKWIS KDQLEKLHAA FLNTPERHVG
     IDELRIILEE LDITFNDSMY TRLFLKINQN RDFKVDWNEF VSYLIFGFQE EDPSSQKESL
     ILPISGPPMV RKSEHRSAIC CLALLKAKSD QVPIDEVTET INFSFGGEDS PEASGMWVTA
     SHEGMMRFWT SHMEPIRTAS SESIVSTYAF YNNGKVHSKL ILGDYAGNVR ILSYSPHLRG
     PFQAKPGAAL IEVIWSDVLK GKIPQFFPKE YINLHNEMIS CVYFSLHMNA LFASAEYRNT
     KKYRGRCPGM IMVNYDERSN FRIPLGVSTF FVAESHNIVV TGGPDTFVRI WDVYIPTEPS
     AILTGHNGGI VLVFVQPEEN KVYSVDYQKI IKVWDLHEHT LLQTYGDLVR LIHHSETDMT
     YYYHSHLQEL VVAGRKLISI KCCPRVRVDL ADGNTHAAPV SVVLYNRLFR NVVSCGLDSY
     IIVWDPWTGR RKIIMKSCHT KMIYGEIIDI EITAACFDPL EQFLLTGARD GSLKIWNYNN
     AVVVRNMSIM PDQEVTAVIW VVDRILPMGW DWQVTEFNDV VGREYGDPKK WPKFHTDDIT
     CADVKLGEGV VTATYSGEII FWKLETGQPY RRYSVMDPTR FIELKLTAEE EKFIRQSKRL
     ASRPTPGNHG LQMGRAGRST VLNRPEDNRD YGTDIPISVQ AVLFLQTRPQ TLKHGSVFIS
     LDTGFIQVYS HHQRGGYMVE FLAVHKTGDC VLTMCTDRKN RYLYTGTAFG YIKVWHIENF
     CVPETEKIHV CMPKLRLEFI FLRKELFLTR AKRAVRNQAE PLLVSSYKGH LKAINSISFI
     NLPKIIFTGS HDYSCRLWTQ GGRYLGTLGT VLPWSKLTPF ERAGNDNHLY RMPPDIKKVA
     SSTTLKVISG IQAETRIKIS DGKPVEDREE DTAQTEDVTE LRKLLDKPVK EPILGKHFEL
     PGRSVLDQHI ELDTTQSYIA VFTQLKVHST EMLERLPTPA VVSRVQTENY LDHYIPVEGK
     VDVSGSAINI KQPSRRRSDK TNDTRNVRTP RARDLIALEM SSSHASQS