ID   WECBH_METMP             Reviewed;         357 AA.
AC   Q6M0B4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=UDP-N-acetylglucosamine 2-epimerase homolog;
DE            EC=5.1.-.-;
GN   OrderedLocusNames=MMP0357;
OS   Methanococcus maripaludis (strain S2 / LL).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=267377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2 / LL;
RX   PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA   Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA   Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA   Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA   Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA   Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA   Olson M.V., Leigh J.A.;
RT   "Complete genome sequence of the genetically tractable hydrogenotrophic
RT   methanogen Methanococcus maripaludis.";
RL   J. Bacteriol. 186:6956-6969(2004).
RN   [2]
RP   LACK OF FUNCTION AS A UDP-GLCNAC EPIMERASE.
RC   STRAIN=900;
RX   PubMed=18263721; DOI=10.1128/jb.01970-07;
RA   Namboori S.C., Graham D.E.;
RT   "Acetamido sugar biosynthesis in the Euryarchaea.";
RL   J. Bacteriol. 190:2987-2996(2008).
CC   -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Despite its similarity with the UDP-N-acetylglucosamine 2-
CC       epimerase enzymes, it does not display UDP-GlcNAc 2-epimerase activity.
CC       {ECO:0000305}.
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DR   EMBL; BX950229; CAF29913.1; -; Genomic_DNA.
DR   RefSeq; WP_011170301.1; NC_005791.1.
DR   AlphaFoldDB; Q6M0B4; -.
DR   SMR; Q6M0B4; -.
DR   STRING; 267377.MMP0357; -.
DR   EnsemblBacteria; CAF29913; CAF29913; MMP0357.
DR   GeneID; 2761372; -.
DR   KEGG; mmp:MMP0357; -.
DR   PATRIC; fig|267377.15.peg.360; -.
DR   eggNOG; arCOG01392; Archaea.
DR   HOGENOM; CLU_041674_0_1_2; -.
DR   OMA; WFPYPEE; -.
DR   OrthoDB; 18594at2157; -.
DR   BioCyc; MMAR267377:MMP_RS01910-MON; -.
DR   Proteomes; UP000000590; Chromosome.
DR   GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
DR   InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR   InterPro; IPR029767; WecB-like.
DR   PANTHER; PTHR43174; PTHR43174; 1.
DR   Pfam; PF02350; Epimerase_2; 1.
DR   TIGRFAMs; TIGR00236; wecB; 1.
PE   1: Evidence at protein level;
KW   Isomerase; Reference proteome.
FT   CHAIN           1..357
FT                   /note="UDP-N-acetylglucosamine 2-epimerase homolog"
FT                   /id="PRO_0000337834"
SQ   SEQUENCE   357 AA;  40851 MW;  D5EBF99B15132F02 CRC64;
     MKIVTIVGAR PQFIKLAPVS KEIRRHFEEI IIHTGQHYDF EMDKIFFDEL EIPTPNYNLN
     IGSGSHGFQT GEMLKKIEEI LLKEKPDLVL VYGDTNSTIA GALAGSKLNI KIAHVEAGLR
     SFDRKMPEEI NRVLTDHISN ILFTPTETAD INLKNEGINS GIFNVGDVMY DSLLNALKLI
     EKKNFKILDE LNISKKKYIL ATVHRAENTD IKENLENIIN AFIESNEKII FPVHPRTRKY
     LEKYRLFEKI KNYDNLKLIS PVGYLEMIYL ENNAKKILTD SGGVQKEAYF LKVPCVTLRN
     NTEWVETVLD GWNILVGSNK EKILENISKF NPASETYNYR FGEGNSSVKI VEVLRNL