ID   WEFC_STRGN              Reviewed;         333 AA.
AC   Q83YR8;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Receptor polysaccharide phosphotransferase WefC;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein WefC;
GN   Name=wefC;
OS   Streptococcus gordonii.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1302;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=38;
RX   PubMed=12949094; DOI=10.1128/jb.185.18.5419-5430.2003;
RA   Xu D.-Q., Thompson J., Cisar J.O.;
RT   "Genetic loci for coaggregation receptor polysaccharide biosynthesis in
RT   Streptococcus gordonii 38.";
RL   J. Bacteriol. 185:5419-5430(2003).
RN   [2]
RP   GENE EXCHANGE WITH WEFF OF S.MITIS.
RC   STRAIN=38;
RX   PubMed=16164562; DOI=10.1111/j.1365-2958.2005.04820.x;
RA   Yoshida Y., Ganguly S., Bush C.A., Cisar J.O.;
RT   "Carbohydrate engineering of the recognition motifs in streptococcal co-
RT   aggregation receptor polysaccharides.";
RL   Mol. Microbiol. 58:244-256(2005).
RN   [3]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- FUNCTION: Part of the type 2Gn receptor polysaccharide (RPS)
CC       biosynthesis locus. Essential for cell surface RPS production, and for
CC       synthesis of the host-like GalNAc beta 1-3Gal (Gn) motif of the RPS.
CC       Probably encodes a 1-3Gal alpha transferase.
CC   -!- MISCELLANEOUS: The cell wall polysaccharides of some oral streptococci
CC       act as receptors for the lectin-like surface adhesins on other members
CC       of the oral biofilm community, especially type 2 fimbriated strains of
CC       Actinomyces naeslundii, allowing colonization of the human tooth
CC       surface. Recognition of these receptor polysaccharides (RPS) depends on
CC       the presence of a host-like motif, either GalNAc beta 1-3Gal (Gn) or
CC       Gal beta 1-3GalNAc (G), within the oligosaccharide repeating units of
CC       different RPS structural types. Type 2Gn RPS of S.gordonii strain 38
CC       and type 2G RPS of S.mitis strain J22 are composed of heptasaccharide
CC       repeats that are identical except for their host-like motifs. This
CC       mimicry of the host glycoconjugates may help the bacteria evade the
CC       immune system.
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; AY147914; AAN64563.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q83YR8; -.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..333
FT                   /note="Receptor polysaccharide phosphotransferase WefC"
FT                   /id="PRO_0000235964"
SQ   SEQUENCE   333 AA;  38506 MW;  D7D3946AFDF27BC1 CRC64;
     MVEKIDFVVA WVDGNDLVWR EKKAQYDGSI NTFKEGMNSE KSYREWGTFK YWFRGVEKFA
     PWVNKIYLVT DQQKPSWLDI NSEKLVLVDH TEIICNDYLP VFSANPIESN IHRIPGLSEH
     FVFFNDDMYL TAPVEPIDFF SEDGLPKYVT ALAPITTERY GTGHFQMNDM GIITSHFSKK
     EILNNGHFFS FKHGIKQLIK TLLYGTTKFI CGFWESHLPY PLLKSTMDLV WEKEKAVLET
     TSASRFRSPS DTNVWLFKYW QIASGQYAIG NPKLGGLFSL DNAGPDFWKL LNSGKYQIMC
     INDGHNVQDE EQVMTDFVKA MDQLLPDKSS FEI