ID   WEFC_STROR              Reviewed;         332 AA.
AC   Q6L5S6;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Receptor polysaccharide phosphotransferase WefC;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein WefC;
GN   Name=wefC;
OS   Streptococcus oralis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Yoshida Y., Cisar J.O.;
RT   "Genetic basis of coaggregation receptor polysaccharide structure and
RT   function.";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; AB181234; BAD22622.1; -; Genomic_DNA.
DR   RefSeq; WP_061421395.1; NZ_KQ970370.1.
DR   AlphaFoldDB; Q6L5S6; -.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..332
FT                   /note="Receptor polysaccharide phosphotransferase WefC"
FT                   /id="PRO_0000235966"
SQ   SEQUENCE   332 AA;  38349 MW;  4915DA820AE81C1C CRC64;
     MNKIDFVVTW VDGGDPIWQA KKAKYSGAVD TSKNSMNSVK AYRDWGTFKY WFRGVEKFAP
     WVNKVYLVTD QQKPSWLDIN SEKLVLVDHT EIICNDYLPV FSANPIESNI HRIPGLSEHF
     VFFNDDMYLT APVEPTDFFS EDGLPKYNTA LSPIIPERYG TGNFQVNDME IVTSYFSRNE
     ILKNGQFFDP KQGLKSIVKS LLYRNSQFIC GFWESHLPYP LLRSTMNLVW EKEKAVLERT
     SASRFRNPSD TNVWLFKYWQ IASGKYAIGN PKLGGLFSLD NAGPDFWKIL NSGKYQIMCI
     NDGFNIQDEE QVMTDFIKAM DQLLPDRSSF EI