ID   WETA_BEAB2              Reviewed;         639 AA.
AC   J5JPY5;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Developmental regulatory protein wetA {ECO:0000305};
GN   Name=wetA {ECO:0000303|PubMed:26243054}; ORFNames=BBA_06126;
OS   Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS   (Tritirachium shiotae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX   NCBI_TaxID=655819;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 2860;
RX   PubMed=22761991; DOI=10.1038/srep00483;
RA   Xiao G., Ying S.-H., Zheng P., Wang Z.-L., Zhang S., Xie X.-Q., Shang Y.,
RA   St Leger R.J., Zhao G.-P., Wang C., Feng M.-G.;
RT   "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT   Beauveria bassiana.";
RL   Sci. Rep. 2:483-483(2012).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX   PubMed=26243054; DOI=10.1007/s00253-015-6823-7;
RA   Li F., Shi H.Q., Ying S.H., Feng M.G.;
RT   "WetA and VosA are distinct regulators of conidiation capacity, conidial
RT   quality, and biological control potential of a fungal insect pathogen.";
RL   Appl. Microbiol. Biotechnol. 99:10069-10081(2015).
CC   -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC       development and conidium maturation (By similarity). They act
CC       individually and together to regulate their own expression and that of
CC       numerous other sporulation-specific genes (By similarity). Acts as a
CC       crucial regulator of both conidiation capacity and conidial quality
CC       (PubMed:26243054). Plays a role in virulence (PubMed:26243054).
CC       {ECO:0000250|UniProtKB:P22022, ECO:0000269|PubMed:26243054}.
CC   -!- DISRUPTION PHENOTYPE: Leads to slower germination, lower hydrophobivity
CC       and lower virulence of conidia (PubMed:26243054).
CC       {ECO:0000269|PubMed:26243054}.
CC   -!- SIMILARITY: Belongs to the wetA family. {ECO:0000305}.
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DR   EMBL; JH725166; EJP64951.1; -; Genomic_DNA.
DR   RefSeq; XP_008599445.1; XM_008601223.1.
DR   AlphaFoldDB; J5JPY5; -.
DR   SMR; J5JPY5; -.
DR   STRING; 655819.J5JPY5; -.
DR   EnsemblFungi; EJP64951; EJP64951; BBA_06126.
DR   GeneID; 19889138; -.
DR   HOGENOM; CLU_020420_0_0_1; -.
DR   InParanoid; J5JPY5; -.
DR   PHI-base; PHI:5054; -.
DR   Proteomes; UP000002762; Unassembled WGS sequence.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR040112; WetA.
DR   PANTHER; PTHR22934:SF23; PTHR22934:SF23; 1.
PE   2: Evidence at transcript level;
KW   Activator; Conidiation; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..639
FT                   /note="Developmental regulatory protein wetA"
FT                   /id="PRO_0000435931"
FT   REGION          65..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          587..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..97
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..224
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..613
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   639 AA;  66959 MW;  BF9FEB1EC8137E9E CRC64;
     MALWTSSYPV DTGDRDPSFA WPDTDVPSAG LDESQHDLFA QFLDFEAGHG STSSATVAVA
     EPFYMDPSHH HHHPHHHAHG ESSTTSSGVS NADEFDFLSS SSNPGAAGYD VDPSTLAMFA
     QDPAAMYSTT SGVTVSDTEL ERLEGISLHS PKKGDGTFAD RAASPTPVAA PAIAVNATTN
     AANTTTNARR SKKIVDALSS TFRKATTMRK TRKVSQTLQR AVSPSMENPP MAIKPGSAQS
     AAPVPRGRRA HRAHTQHALQ HQQQQHQHQQ QQAHQISESP PILQINTGLA NSGGFVAGQF
     EDPFGGEISP THAPQPQSQP PQMRYYSQGG LGTPLDSPTR SAAMLQQQWQ QQQQQQHNGA
     QQHQWSAASS QQELWWGGAA GGGAIEAKNI DANMAMHSQH GELPYDVHAD AGRVAPNGLL
     IHMPQPRPGS SSVHDLSLNA HTYLPPPPPV PTENTRSARP PRAPSSGARH HHRTTSSSPM
     RKQRGTSVSP SPGGNGSGGG TRQSRHSSGG SAASSSQRSA SGRVSVPGTP SSSGIKKRRS
     RDAGSGSFSA DEAGGFTLVG GGGGGGGGGG GGGIGFVNFT PNDGGVLMTG VAPSGSSKTK
     ARREKEAQER RRRLSEAAMK AVAAAGGDIR KLREQGFEL