WETA_GIBZE
ID WETA_GIBZE Reviewed; 608 AA.
AC I1S0E2; A0A0E0RWA0;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2016, sequence version 2.
DT 25-MAY-2022, entry version 41.
DE RecName: Full=Developmental regulatory protein wetA {ECO:0000305};
GN Name=wetA {ECO:0000303|PubMed:24186953}; ORFNames=FGRRES_17727, FGSG_10166;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24186953; DOI=10.1128/ec.00220-13;
RA Son H., Kim M.G., Min K., Lim J.Y., Choi G.J., Kim J.C., Chae S.K.,
RA Lee Y.W.;
RT "WetA is required for conidiogenesis and conidium maturation in the
RT ascomycete fungus Fusarium graminearum.";
RL Eukaryot. Cell 13:87-98(2014).
RN [5]
RP INDUCTION.
RX PubMed=25277408; DOI=10.1007/s12275-014-4384-6;
RA Son H., Kim M.G., Chae S.K., Lee Y.W.;
RT "FgFlbD regulates hyphal differentiation required for sexual and asexual
RT reproduction in the ascomycete fungus Fusarium graminearum.";
RL J. Microbiol. 52:930-939(2014).
CC -!- FUNCTION: AbaA and wetA are pivotal regulators of conidiophore
CC development and conidium maturation (By similarity). They act
CC individually and together to regulate their own expression and that of
CC numerous other sporulation-specific genes (By similarity). Functions to
CC maintain conidial dormancy by suppressing microcycle conidiation
CC (PubMed:24186953). {ECO:0000250|UniProtKB:P22022,
CC ECO:0000269|PubMed:24186953}.
CC -!- INDUCTION: Expression is positively regulated by flbD
CC (PubMed:25277408). {ECO:0000269|PubMed:25277408}.
CC -!- DISRUPTION PHENOTYPE: Results in abnormal production of conidiophores
CC and conidia, including longer conidia with fewer septa, conidia
CC sensitivity to acute stresses such as oxidative stress and heat stress,
CC and vigorous generation of single-celled conidia through autophagy-
CC dependent microcycle conidiation (PubMed:24186953). Reduces the
CC survival rate of aged conidia (PubMed:24186953).
CC {ECO:0000269|PubMed:24186953}.
CC -!- SIMILARITY: Belongs to the wetA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ESU16845.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; DS231669; ESU16845.1; ALT_INIT; Genomic_DNA.
DR EMBL; HG970332; CEF75525.1; -; Genomic_DNA.
DR RefSeq; XP_011319107.1; XM_011320805.1.
DR AlphaFoldDB; I1S0E2; -.
DR STRING; 229533.I1S0E2; -.
DR EnsemblFungi; ESU16845; ESU16845; FGSG_10166.
DR GeneID; 23557084; -.
DR KEGG; fgr:FGSG_10166; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G07441; -.
DR eggNOG; ENOG502S8IT; Eukaryota.
DR HOGENOM; CLU_100289_0_0_1; -.
DR InParanoid; I1S0E2; -.
DR Proteomes; UP000070720; Chromosome 1.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Activator; Conidiation; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..608
FT /note="Developmental regulatory protein wetA"
FT /id="PRO_0000435928"
FT REGION 54..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..336
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..465
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 66196 MW; 4509D2540A5DEE48 CRC64;
MPMASWTLPY RVEAVDRDPG FYWQEIEDGH NNDGSADFFG QFINFDSEIP SSMADHHGHN
PGMPTLADGL MLDHPSESTA SASSGVSTTE DEFDLFSCSS QVDATVPSQP GSSAAPGASH
DVDPRSLALA DSSGLMVEKH SMVPRVSMSD PELPRVDGIS LQSSPGRRVP VSQPSSPTPP
NTMTRKPNKF VEALSSTIRK ASKLRKPRKP IAMDRPGSPT MDNPPRALRL QHHEYNGNDV
FPPSPTTCGP DSTNFVHGFC DDPFDEIPQQ HPNNMRFFKT NGIHTPAESP GIKTEPGMYQ
PEMAGQAVWP HQQHPHPHPH PHHPQAHTHP HPHPHPHPHQ QAVAGHPQHA VPVVGPAPET
WPGHEYMAQN AHQSGWWDLN LLNQNGEYVV VDPQQQKNAN LNLAMHAQHA ELPYEYQVHD
PNSAGLMIHM PQPRNDSTPA HDLALNAQTY LPPPPPIPPT TERHRPPRAP SSGARHLSCS
PIRKTRQPSI PPTPTTVHSR HSSNGSVASA RSASGRGMVP GTPTAMRKQR RSRDSSGGSV
GDIGFVNFTP SDGGLLMTGV APSGSSKTKA RREREAMERR RRLSEAAMKA VQAAGGDVDK
LMEQGFAF
