WETA_METRA
ID WETA_METRA Reviewed; 645 AA.
AC E9ES99;
DT 05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=Developmental regulatory protein wetA {ECO:0000303|PubMed:28447400};
GN Name=WetA {ECO:0000303|PubMed:28447400}; ORFNames=MAA_02845;
OS Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS anisopliae (strain ARSEF 23)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX NCBI_TaxID=655844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 23 / ATCC MYA-3075;
RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA Zhong Y., Ma L.-J., St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y.,
RA Wang C.;
RT "Genome sequencing and comparative transcriptomics of the model
RT entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL PLoS Genet. 7:E1001264-E1001264(2011).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ARSEF 23 / ATCC MYA-3075;
RX PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA St Leger R.J., Wang C.;
RT "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT adaptation.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
RN [3]
RP IDENTIFICATION, FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28447400; DOI=10.1111/1462-2920.13777;
RA Zeng G., Chen X., Zhang X., Zhang Q., Xu C., Mi W., Guo N., Zhao H.,
RA You Y., Dryburgh F.J., Bidochka M.J., St Leger R.J., Zhang L., Fang W.;
RT "Genome-wide identification of pathogenicity, conidiation and colony
RT sectorization genes in Metarhizium robertsii.";
RL Environ. Microbiol. 19:3896-3908(2017).
CC -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC development and conidium maturation. They act individually and together
CC to regulate their own expression and that of numerous other
CC sporulation-specific genes (PubMed:28447400). BrlA, abaA and wetA act
CC together to positively regulate the expression of the Pks1 gene cluster
CC that mediates the biosynthesis of an anthraquinone derivative pigment
CC that contributes to conidial pigmentation that provides protection from
CC UV radiation, heat and cold stress (PubMed:28447400).
CC {ECO:0000269|PubMed:28447400}.
CC -!- INDUCTION: Expression remains constant during conidiation
CC (PubMed:28447400). Expression is positively regulated by BrlA and AbaA
CC (PubMed:28447400). {ECO:0000269|PubMed:28447400}.
CC -!- DISRUPTION PHENOTYPE: Produces fewer branches per conidiophore and thus
CC has significantly lower conidial yields. {ECO:0000269|PubMed:28447400}.
CC -!- SIMILARITY: Belongs to the wetA family. {ECO:0000305}.
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DR EMBL; ADNJ02000004; EFZ01616.1; -; Genomic_DNA.
DR RefSeq; XP_007819034.1; XM_007820843.1.
DR AlphaFoldDB; E9ES99; -.
DR EnsemblFungi; EFZ01616; EFZ01616; MAA_02845.
DR GeneID; 19257131; -.
DR KEGG; maj:MAA_02845; -.
DR HOGENOM; CLU_020420_0_0_1; -.
DR Proteomes; UP000002498; Unassembled WGS sequence.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Activator; Conidiation; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..645
FT /note="Developmental regulatory protein wetA"
FT /id="PRO_0000445754"
FT REGION 158..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..361
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 645 AA; 70348 MW; 875E70F45F72DD8C CRC64;
MAFWTVPYRA EAVDTNRDPS MYWEDINSAS TDDAHNDFFG QFVDFDADGT VTATTDNDFN
TVPASMPGVP ESMLLMGDRT VATLESAVSS CVSSADEFDF LSSSSRIGPT ASAASHEIDP
KDLTLSADEL AHPSQQQFDY LGRGSMSEAD LSRLESISLH SPQRPQNTTS SDTPSPKPPN
TDARKPKKFV EALSSTIRKA TNLRRNRKAA AVPRQVSPPQ EHLQPLKIPK QRRGRGRAVT
QGNLPVSPPL QQQEQATPHF IHGQCDDPFN DTALLPPGGV NLQYYGQVAP DTPVESPGVK
NEPNQSHFQV DMAWQHHHHP HHHHQQQQHP PPPPHPHPHP HHHQQQQQQH QHQHQHHHQQ
QQHHQQQQQQ QHQMHWTGTG GEYITSQEAG WWTPNMMSQG PNDFSHHQRS ASVHVMGHGQ
HTGMPYDYGA IADTSTGGLM IHMPQPRGSQ SSVVNDLTVN AQTFLPPPPP IPQAIGQKMP
GSERSHRPPK AKSSGARHLS CSPVRKQRGP SSSPTPADQS AVPRSRHSSG ASVSSLRSSS
GRLPASMPGT PCSVRKRRSR DISGSNSATS LGGSDGASGI GFVNFTPNDG SVLMTGVAPS
GSSKTKARRE KEAQDRRRRL SEAAIKAVAA AGGDVDKLIE QGFAF
