ID   WETA_PEND2              Reviewed;         520 AA.
AC   K9FWK0;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Developmental regulatory protein wetA {ECO:0000305};
GN   Name=wetA {ECO:0000303|PubMed:25530311}; ORFNames=PDIG_73870;
OS   Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1170229;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PHI26 / CECT 20796;
RX   PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA   Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA   Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT   "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT   postharvest pathogen of citrus.";
RL   BMC Genomics 13:646-646(2012).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25530311; DOI=10.1016/j.resmic.2014.12.003;
RA   Wang M., Sun X., Zhu C., Xu Q., Ruan R., Yu D., Li H.;
RT   "PdbrlA, PdabaA and PdwetA control distinct stages of conidiogenesis in
RT   Penicillium digitatum.";
RL   Res. Microbiol. 166:56-65(2015).
CC   -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC       development and conidium maturation (By similarity). They act
CC       individually and together to regulate their own expression and that of
CC       numerous other sporulation-specific genes (By similarity). Plays a
CC       crucial role in pigmentation and conidial cell wall integrity
CC       (PubMed:25530311). {ECO:0000250|UniProtKB:P22022,
CC       ECO:0000269|PubMed:25530311}.
CC   -!- DISRUPTION PHENOTYPE: Totally blocks pigmentation of conidia and leads
CC       to colonies with on a white tinge (PubMed:25530311).
CC       {ECO:0000269|PubMed:25530311}.
CC   -!- SIMILARITY: Belongs to the wetA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AKCT01000266; EKV07113.1; -; Genomic_DNA.
DR   AlphaFoldDB; K9FWK0; -.
DR   STRING; 1170229.K9FWK0; -.
DR   EnsemblFungi; EKV07113; EKV07113; PDIG_73870.
DR   eggNOG; ENOG502S8IT; Eukaryota.
DR   HOGENOM; CLU_030750_0_0_1; -.
DR   InParanoid; K9FWK0; -.
DR   OMA; MAYQEAW; -.
DR   OrthoDB; 638649at2759; -.
DR   Proteomes; UP000009882; Unassembled WGS sequence.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR040112; WetA.
DR   PANTHER; PTHR22934:SF23; PTHR22934:SF23; 2.
PE   3: Inferred from homology;
KW   Activator; Conidiation; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..520
FT                   /note="Developmental regulatory protein wetA"
FT                   /id="PRO_0000435929"
FT   REGION          110..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          260..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          471..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..415
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..496
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  57121 MW;  09BE25014D1E2E5B CRC64;
     MFAQPYDHSF NDLFNQYVNM ETSAADGKDS TLSDFDQLFP LDSLSSDCGD LPPTVSTPNC
     HQSPQPWSNE WSLQNDGPAV DHFAFHDTVP LSAISDVNLN NFEVLSRPTA THALSTSPST
     PPATPRRKPT QSALITPKSI RHRCPNERRS HLCKQSFSPS LMRSSNLSKA RMAYPEAWAQ
     QIQSFSLQSS EDRLPLSPPP SDVLIQHENR PAEQIMHQTR DSVEMPSQYD ARLYHQPPSV
     SMPSPNIAMS ARQPQHYIAH PSSSTLTNSS PSSADDMFSS SHSSDPHSLS SWQSDHLHPP
     SFSFTPDLQC QDSQWWSPMT SRVAQQQASY LTSPTPVRTM QSVGSQNDIM QGGLMIQFNP
     SYDMPADHSF SSNNMLPVAP QKFDTSFTTS QVHNVSRSPS LSPKAGTSPR DTHNGSISKP
     VHRRTHSRKL SGQSMNAPKP AKASGSSSRG SNKSVSVSFV NFTAHDSKKI LTGVAPSGSS
     KTKARREQEA RDRRRKLSEA ALRAVRSAGG DVEALEAVLC