ID   WETA_PENRF              Reviewed;         520 AA.
AC   W6QM20;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 22.
DE   RecName: Full=Developmental regulatory protein wetA {ECO:0000305};
GN   Name=wetA {ECO:0000303|PubMed:25811807}; ORFNames=PROQFM164_S05g000864;
OS   Penicillium roqueforti (strain FM164).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1365484;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FM164;
RX   PubMed=24407037; DOI=10.1038/ncomms3876;
RA   Cheeseman K., Ropars J., Renault P., Dupont J., Gouzy J., Branca A.,
RA   Abraham A.L., Ceppi M., Conseiller E., Debuchy R., Malagnac F., Goarin A.,
RA   Silar P., Lacoste S., Sallet E., Bensimon A., Giraud T., Brygoo Y.;
RT   "Multiple recent horizontal transfers of a large genomic region in cheese
RT   making fungi.";
RL   Nat. Commun. 5:2876-2876(2014).
RN   [2]
RP   INDUCTION.
RX   PubMed=25811807; DOI=10.1371/journal.pone.0120740;
RA   Gil-Duran C., Rojas-Aedo J.F., Medina E., Vaca I., Garcia-Rico R.O.,
RA   Villagran S., Levican G., Chavez R.;
RT   "The pcz1 gene, which encodes a Zn(II)2Cys6 protein, is involved in the
RT   control of growth, conidiation, and conidial germination in the filamentous
RT   fungus Penicillium roqueforti.";
RL   PLoS ONE 10:E0120740-E0120740(2015).
CC   -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC       development and conidium maturation (By similarity). They act
CC       individually and together to regulate their own expression and that of
CC       numerous other sporulation-specific genes (By similarity).
CC       {ECO:0000250|UniProtKB:P22022}.
CC   -!- INDUCTION: Expression is positively regulated by pcz1
CC       (PubMed:25811807). {ECO:0000269|PubMed:25811807}.
CC   -!- SIMILARITY: Belongs to the wetA family. {ECO:0000305}.
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DR   EMBL; HG792019; CDM37031.1; -; Genomic_DNA.
DR   AlphaFoldDB; W6QM20; -.
DR   STRING; 1365484.W6QM20; -.
DR   EnsemblFungi; CDM37031; CDM37031; PROQFM164_S05g000864.
DR   OrthoDB; 638649at2759; -.
DR   Proteomes; UP000030686; Unassembled WGS sequence.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR040112; WetA.
DR   PANTHER; PTHR22934:SF23; PTHR22934:SF23; 2.
PE   2: Evidence at transcript level;
KW   Activator; Conidiation; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..520
FT                   /note="Developmental regulatory protein wetA"
FT                   /id="PRO_0000435930"
FT   REGION          109..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          378..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          468..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..414
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..454
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..496
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  57306 MW;  CD00C5ADC2C19649 CRC64;
     MFAQQYDHSF NDLFNQYVNM ETSAADGKDS ALSEFDQLFP LDSLSNDCGD LAPTVSTPKC
     HQSPQPWSNE WSLQYDGPAA DHFAFHDTVH PSAISDVNLN HFEVPSRPTA THALSISPST
     PPATPRRKPT QSALITPKTI RHRSPNERRS HLRKQSFSPS LMRSSNLSKS RMAYPEAWAQ
     RLQNFSLHNS EDRLPLSPPP SDALIQHENM PTEQIMNQSR DSAEMPPQYD ARLYHQSPSV
     PMQSPSIAMS ARQQQHYIAH PSSSALTNSS PSSADDIFSL SHSSDLHSLS SWQSDSLHAS
     SLPFTPDLQG QESQWWSPMP SRVAQQQAAY LASPTPVRHM QNVGSQNDIM QGGLMIQFNP
     SYDMSADHSF SSNMLPTSSQ KFDTSYTSSQ VHDISRSSSS LSPKTGTSPR DTHHGSISKP
     THRRTHSRKL SSQSMNTPKP AKAPSSSSRG SNKSVSVSFV NFTADDSKKI LTGVAPSGSS
     KTKARREQEA RDRRRKLSEA ALRAVRSAGG DVEALEAVLC