WETA_PENRW
ID WETA_PENRW Reviewed; 520 AA.
AC Q01870; B6HRB1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Developmental regulatory protein wetA {ECO:0000305};
GN Name=wetA {ECO:0000303|PubMed:8078481}; ORFNames=Pc22g03220;
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=8078481; DOI=10.1007/bf00583905;
RA Prade R.A., Timberlake W.E.;
RT "The Penicillium chrysogenum and Aspergillus nidulans wetA developmental
RT regulatory genes are functionally equivalent.";
RL Mol. Gen. Genet. 244:539-547(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
RN [3]
RP INDUCTION.
RX PubMed=18364746; DOI=10.1139/o07-148;
RA Garcia-Rico R.O., Fierro F., Martin J.F.;
RT "Heterotrimeric Galpha protein Pga1 of Penicillium chrysogenum controls
RT conidiation mainly by a cAMP-independent mechanism.";
RL Biochem. Cell Biol. 86:57-69(2008).
CC -!- FUNCTION: BrlA, abaA and wetA are pivotal regulators of conidiophore
CC development and conidium maturation (By similarity). They act
CC individually and together to regulate their own expression and that of
CC numerous other sporulation-specific genes (By similarity). Responsible
CC for activating a set of genes whose products make up the final two
CC conidial wall layers or direct their assembly and though this activity
CC is responsible for acquisition of spore dormancy (PubMed:8078481).
CC {ECO:0000250|UniProtKB:P22022, ECO:0000269|PubMed:8078481}.
CC -!- INDUCTION: Expression is regulated by the heterotrimeric G protein pga1
CC (PubMed:18364746). {ECO:0000269|PubMed:18364746}.
CC -!- SIMILARITY: Belongs to the wetA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA56364.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X80058; CAA56364.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AM920437; CAP97610.1; -; Genomic_DNA.
DR PIR; S46660; S46660.
DR RefSeq; XP_002564365.1; XM_002564319.1.
DR AlphaFoldDB; Q01870; -.
DR STRING; 1108849.XP_002564365.1; -.
DR EnsemblFungi; CAP97610; CAP97610; PCH_Pc22g03220.
DR GeneID; 8311640; -.
DR KEGG; pcs:Pc22g03220; -.
DR VEuPathDB; FungiDB:PCH_Pc22g03220; -.
DR eggNOG; ENOG502S8IT; Eukaryota.
DR HOGENOM; CLU_030750_0_0_1; -.
DR OMA; MAYQEAW; -.
DR OrthoDB; 638649at2759; -.
DR Proteomes; UP000000724; Contig Pc00c22.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR040112; WetA.
DR PANTHER; PTHR22934:SF23; PTHR22934:SF23; 2.
PE 2: Evidence at transcript level;
KW Activator; Conidiation; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..520
FT /note="Developmental regulatory protein wetA"
FT /id="PRO_0000065962"
FT REGION 49..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 226
FT /note="P -> A (in Ref. 1; CAA56364)"
FT /evidence="ECO:0000305"
FT CONFLICT 328
FT /note="A -> G (in Ref. 1; CAA56364)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 520 AA; 56885 MW; D8AAEC1AF1761521 CRC64;
MFAQPYDHSF NDLFNQYVNM ETSAVDGKDS ALSDFDQLFP LDSLSSDCGD LPPTVSTPKR
HQSPQPWSNE WSLQDDGAAA DHFAFHDTVH PSAISDVNLN NFEVPSRPTA SHGLSTSPST
PPATPRRKPT QSALITPKSI RHRSPNERRS HLRKQSFSPS LMRSSNLSKA RMAYPEAWAQ
RLQNFSLHGS EDRLPLSPPP SDVLIQHENM PTEQIMNQHG DSAERPSQYD ARLYQQSPSV
SMPSPSIAMS ARQQQHYIAQ PSSSSLTNSS PSSADDIFSS SHSSDPHSLS SWQSDPLHAS
SLSFTPDLQG QDSQWWSPMP SRVAQQQAAY LTSPTPVRTM QSVGSQNDMM QGGLMIQFNP
SYDMSADHSF SSSNMLPATP QKFDTSFNTS QVHNVSRSPS LSPKAGTSPR DTRNGSISKP
THRRTHSRKL SGQSMNAPKP AKASGSSSRG SNKSVSVSFV NFTAHDSKKI LTGVAPSGSS
KTKARREQEA RDRRRKLSEA ALRAVRSAGG DVEALEAVLC
