WF10B_HUMAN
ID WF10B_HUMAN Reviewed; 73 AA.
AC Q8IUB3; A6PVD7; Q0VAG0; Q0VAG1; Q5TGZ5; Q8IUB4;
DT 16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2003, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Protein WFDC10B;
DE Flags: Precursor;
GN Name=WFDC10B; Synonyms=WAP12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=12206714; DOI=10.1042/bj20020869;
RA Clauss A., Lilja H., Lundwall A.;
RT "A locus on human chromosome 20 contains several genes expressing protease
RT inhibitor domains with homology to whey acidic protein.";
RL Biochem. J. 368:233-242(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PRO-8.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8IUB3; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-10261124, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=WAP12a;
CC IsoId=Q8IUB3-1; Sequence=Displayed;
CC Name=2; Synonyms=WAP12b;
CC IsoId=Q8IUB3-2; Sequence=VSP_007552;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
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DR EMBL; AF454506; AAN70989.1; -; mRNA.
DR EMBL; AF454507; AAN70990.1; -; mRNA.
DR EMBL; AL031671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL109656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75823.1; -; Genomic_DNA.
DR EMBL; BC121071; AAI21072.1; -; mRNA.
DR EMBL; BC121072; AAI21073.1; -; mRNA.
DR CCDS; CCDS13365.1; -. [Q8IUB3-2]
DR CCDS; CCDS13366.1; -. [Q8IUB3-1]
DR RefSeq; NP_742003.1; NM_172006.2. [Q8IUB3-1]
DR RefSeq; NP_742143.1; NM_172131.2. [Q8IUB3-2]
DR RefSeq; XP_016883313.1; XM_017027824.1. [Q8IUB3-1]
DR RefSeq; XP_016883314.1; XM_017027825.1. [Q8IUB3-1]
DR AlphaFoldDB; Q8IUB3; -.
DR SMR; Q8IUB3; -.
DR BioGRID; 129382; 2.
DR IntAct; Q8IUB3; 1.
DR STRING; 9606.ENSP00000337466; -.
DR iPTMnet; Q8IUB3; -.
DR BioMuta; WFDC10B; -.
DR DMDM; 32130300; -.
DR PaxDb; Q8IUB3; -.
DR PeptideAtlas; Q8IUB3; -.
DR PRIDE; Q8IUB3; -.
DR Antibodypedia; 52050; 2 antibodies from 1 providers.
DR DNASU; 280664; -.
DR Ensembl; ENST00000330523.10; ENSP00000327628.5; ENSG00000182931.10. [Q8IUB3-1]
DR Ensembl; ENST00000335769.2; ENSP00000337466.2; ENSG00000182931.10. [Q8IUB3-2]
DR GeneID; 280664; -.
DR KEGG; hsa:280664; -.
DR MANE-Select; ENST00000330523.10; ENSP00000327628.5; NM_172006.2; NP_742003.1.
DR UCSC; uc002xpb.4; human. [Q8IUB3-1]
DR CTD; 280664; -.
DR GeneCards; WFDC10B; -.
DR HGNC; HGNC:20479; WFDC10B.
DR HPA; ENSG00000182931; Tissue enhanced (epididymis, retina).
DR neXtProt; NX_Q8IUB3; -.
DR OpenTargets; ENSG00000182931; -.
DR PharmGKB; PA134935020; -.
DR VEuPathDB; HostDB:ENSG00000182931; -.
DR eggNOG; ENOG502T9GV; Eukaryota.
DR GeneTree; ENSGT00940000163972; -.
DR HOGENOM; CLU_175686_0_0_1; -.
DR InParanoid; Q8IUB3; -.
DR OMA; HCPQNTI; -.
DR OrthoDB; 1591333at2759; -.
DR PhylomeDB; Q8IUB3; -.
DR PathwayCommons; Q8IUB3; -.
DR SignaLink; Q8IUB3; -.
DR BioGRID-ORCS; 280664; 12 hits in 1024 CRISPR screens.
DR GenomeRNAi; 280664; -.
DR Pharos; Q8IUB3; Tdark.
DR PRO; PR:Q8IUB3; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8IUB3; protein.
DR Bgee; ENSG00000182931; Expressed in cauda epididymis and 92 other tissues.
DR Genevisible; Q8IUB3; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR InterPro; IPR008197; WAP_dom.
DR PROSITE; PS51390; WAP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..73
FT /note="Protein WFDC10B"
FT /id="PRO_0000041388"
FT DOMAIN 28..73
FT /note="WAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT VAR_SEQ 1..31
FT /note="MAPQTLLLVLVLCVLLLQAQGGYRDKMRMQR -> MVSCERRASKSVGQILL
FT WDFGYTCRLSHRRRNSTEILSRNLPALYTG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12206714"
FT /id="VSP_007552"
FT VARIANT 8
FT /note="L -> P (in dbSNP:rs232729)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_052952"
SQ SEQUENCE 73 AA; 8325 MW; EF1E4F057E09C3EE CRC64;
MAPQTLLLVL VLCVLLLQAQ GGYRDKMRMQ RIKVCEKRPS IDLCIHHCSY FQKCETNKIC
CSAFCGNICM SIL
