WF15A_MOUSE
ID WF15A_MOUSE Reviewed; 80 AA.
AC Q8BH89;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=WAP four-disulfide core domain protein 15A {ECO:0000312|MGI:MGI:1915471};
DE Flags: Precursor;
GN Name=Wfdc15a {ECO:0000312|MGI:MGI:1915471};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAC25151.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC25151.1};
RC TISSUE=Testis {ECO:0000312|EMBL:BAC25151.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:AAI00424.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis {ECO:0000312|EMBL:AAI00424.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=15950183; DOI=10.1016/j.bbrc.2005.05.125;
RA Clauss A., Lilja H., Lundwall A.;
RT "The evolution of a genetic locus encoding small serine proteinase
RT inhibitors.";
RL Biochem. Biophys. Res. Commun. 333:383-389(2005).
CC -!- FUNCTION: Antibacterial protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AK006775; BAC25151.1; -; mRNA.
DR EMBL; AK018854; BAC25567.1; -; mRNA.
DR EMBL; AK018888; BAC25569.1; -; mRNA.
DR EMBL; AK018909; BAC25570.1; -; mRNA.
DR EMBL; AL591512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100423; AAI00424.1; -; mRNA.
DR CCDS; CCDS38319.1; -.
DR RefSeq; NP_899094.1; NM_183271.2.
DR AlphaFoldDB; Q8BH89; -.
DR SMR; Q8BH89; -.
DR STRING; 10090.ENSMUSP00000070718; -.
DR MEROPS; I17.002; -.
DR PaxDb; Q8BH89; -.
DR PRIDE; Q8BH89; -.
DR ProteomicsDB; 297555; -.
DR DNASU; 68221; -.
DR Ensembl; ENSMUST00000063251; ENSMUSP00000070718; ENSMUSG00000051769.
DR GeneID; 68221; -.
DR KEGG; mmu:68221; -.
DR UCSC; uc008nty.1; mouse.
DR CTD; 68221; -.
DR MGI; MGI:1915471; Wfdc15a.
DR VEuPathDB; HostDB:ENSMUSG00000051769; -.
DR eggNOG; ENOG502TEXR; Eukaryota.
DR GeneTree; ENSGT00390000002529; -.
DR HOGENOM; CLU_200089_0_0_1; -.
DR InParanoid; Q8BH89; -.
DR OMA; QCMEPWW; -.
DR OrthoDB; 1571744at2759; -.
DR PhylomeDB; Q8BH89; -.
DR TreeFam; TF339673; -.
DR BioGRID-ORCS; 68221; 1 hit in 68 CRISPR screens.
DR ChiTaRS; Wfdc15a; mouse.
DR PRO; PR:Q8BH89; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BH89; protein.
DR Bgee; ENSMUSG00000051769; Expressed in spermatocyte and 21 other tissues.
DR Genevisible; Q8BH89; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 4.10.75.10; -; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 1.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57256; SSF57256; 1.
DR PROSITE; PS51390; WAP; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..80
FT /note="WAP four-disulfide core domain protein 15A"
FT /evidence="ECO:0000255"
FT /id="PRO_0000343831"
FT DOMAIN 29..76
FT /note="WAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 36..64
FT /evidence="ECO:0000250|UniProtKB:P19957,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 43..68
FT /evidence="ECO:0000250|UniProtKB:P19957,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 51..63
FT /evidence="ECO:0000250|UniProtKB:P19957,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 57..72
FT /evidence="ECO:0000250|UniProtKB:P19957,
FT ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 80 AA; 9062 MW; 3FE035FC20684200 CRC64;
MKPSSLLLFT TTILLCLSMA QPRATRKGVT PKQGYCPEFL LDCPFVLLPV CSRDKGCKGT
KKCCFYYCQM RCVEPWTTLT
