WFC6B_MOUSE
ID WFC6B_MOUSE Reviewed; 148 AA.
AC F6ULY1; B2RUM4; E9Q6A8; Q5DQU6;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=WAP four-disulfide core domain protein 6B;
DE AltName: Full=Putative protease inhibitor WAP6B;
DE Flags: Precursor;
GN Name=Wfdc6b; Synonyms=Wfdc6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15950183; DOI=10.1016/j.bbrc.2005.05.125;
RA Clauss A., Lilja H., Lundwall A.;
RT "The evolution of a genetic locus encoding small serine proteinase
RT inhibitors.";
RL Biochem. Biophys. Res. Commun. 333:383-389(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI41217.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAT07038.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAM15023.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY541526; AAT07038.1; ALT_INIT; mRNA.
DR EMBL; AL591478; CAM15023.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC141216; AAI41217.1; ALT_INIT; mRNA.
DR CCDS; CCDS17046.2; -.
DR RefSeq; NP_001012743.2; NM_001012725.2.
DR AlphaFoldDB; F6ULY1; -.
DR SMR; F6ULY1; -.
DR STRING; 10090.ENSMUSP00000091906; -.
DR MEROPS; I02.976; -.
DR MEROPS; I17.953; -.
DR PaxDb; F6ULY1; -.
DR PRIDE; F6ULY1; -.
DR ProteomicsDB; 299978; -.
DR DNASU; 433502; -.
DR Ensembl; ENSMUST00000094346; ENSMUSP00000091906; ENSMUSG00000070531.
DR GeneID; 433502; -.
DR KEGG; mmu:433502; -.
DR UCSC; uc008nvl.2; mouse.
DR CTD; 433502; -.
DR MGI; MGI:3575430; Wfdc6b.
DR VEuPathDB; HostDB:ENSMUSG00000070531; -.
DR eggNOG; KOG4295; Eukaryota.
DR GeneTree; ENSGT00940000156753; -.
DR HOGENOM; CLU_127181_0_0_1; -.
DR InParanoid; F6ULY1; -.
DR OMA; NDPCTES; -.
DR OrthoDB; 1474897at2759; -.
DR PhylomeDB; F6ULY1; -.
DR TreeFam; TF342459; -.
DR BioGRID-ORCS; 433502; 2 hits in 70 CRISPR screens.
DR PRO; PR:F6ULY1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; F6ULY1; protein.
DR Bgee; ENSMUSG00000070531; Expressed in testis and 8 other tissues.
DR Genevisible; F6ULY1; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0010466; P:negative regulation of peptidase activity; IBA:GO_Central.
DR CDD; cd00109; KU; 1.
DR Gene3D; 4.10.410.10; -; 1.
DR Gene3D; 4.10.75.10; -; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00095; WAP; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SUPFAM; SSF57256; SSF57256; 1.
DR SUPFAM; SSF57362; SSF57362; 1.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS51390; WAP; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..148
FT /note="WAP four-disulfide core domain protein 6B"
FT /id="PRO_0000415852"
FT DOMAIN 37..84
FT /note="WAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 88..138
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 43..72
FT /evidence="ECO:0000250"
FT DISULFID 51..76
FT /evidence="ECO:0000250"
FT DISULFID 59..71
FT /evidence="ECO:0000250"
FT DISULFID 65..80
FT /evidence="ECO:0000250"
FT DISULFID 88..138
FT /evidence="ECO:0000250"
FT DISULFID 97..121
FT /evidence="ECO:0000250"
FT DISULFID 113..134
FT /evidence="ECO:0000250"
FT CONFLICT 87
FT /note="I -> V (in Ref. 3; AAI41217)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 148 AA; 17169 MW; 09D0107D895DD249 CRC64;
MPPNRLLLPK MRLWGLLPFL VPFILLWSIQ EPALAEGVFI RTCPKYNKIK CDFEERNQCL
RHRECPGEER CCLFACGRKC LDLSEDICSL PQDAGPCLAY LPRWWYNQDT KLCIEFIYGG
CQGNPNNFES KAVCTSICIN KRKMSSWI
