ID   WFD11_HUMAN             Reviewed;          87 AA.
AC   Q8NEX6; E1P624; Q5TGZ6;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Protein WFDC11;
DE   Flags: Precursor;
GN   Name=WFDC11; Synonyms=WAP11;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12206714; DOI=10.1042/bj20020869;
RA   Clauss A., Lilja H., Lundwall A.;
RT   "A locus on human chromosome 20 contains several genes expressing protease
RT   inhibitor domains with homology to whey acidic protein.";
RL   Biochem. J. 368:233-242(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- MISCELLANEOUS: Although this protein was isolated in a region
CC       containing several WAP proteins and was defined as a WAP protein, it
CC       does not contain a classical WAP domain.
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DR   EMBL; AY047609; AAK97771.1; -; mRNA.
DR   EMBL; AL031671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471077; EAW75824.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75825.1; -; Genomic_DNA.
DR   EMBL; BC062670; AAH62670.1; -; mRNA.
DR   CCDS; CCDS13364.1; -.
DR   RefSeq; NP_671730.1; NM_147197.2.
DR   AlphaFoldDB; Q8NEX6; -.
DR   BioGRID; 129231; 21.
DR   STRING; 9606.ENSP00000348968; -.
DR   iPTMnet; Q8NEX6; -.
DR   PhosphoSitePlus; Q8NEX6; -.
DR   BioMuta; WFDC11; -.
DR   DMDM; 26401306; -.
DR   MassIVE; Q8NEX6; -.
DR   MaxQB; Q8NEX6; -.
DR   PaxDb; Q8NEX6; -.
DR   PeptideAtlas; Q8NEX6; -.
DR   PRIDE; Q8NEX6; -.
DR   ProteomicsDB; 73228; -.
DR   Antibodypedia; 70456; 28 antibodies from 5 providers.
DR   DNASU; 259239; -.
DR   Ensembl; ENST00000324384.4; ENSP00000318753.3; ENSG00000180083.11.
DR   Ensembl; ENST00000356562.6; ENSP00000348968.2; ENSG00000180083.11.
DR   Ensembl; ENST00000618797.4; ENSP00000479579.1; ENSG00000180083.11.
DR   GeneID; 259239; -.
DR   KEGG; hsa:259239; -.
DR   MANE-Select; ENST00000324384.4; ENSP00000318753.3; NM_147197.2; NP_671730.1.
DR   UCSC; uc002xpa.4; human.
DR   CTD; 259239; -.
DR   GeneCards; WFDC11; -.
DR   HGNC; HGNC:20478; WFDC11.
DR   HPA; ENSG00000180083; Tissue enriched (epididymis).
DR   neXtProt; NX_Q8NEX6; -.
DR   OpenTargets; ENSG00000180083; -.
DR   PharmGKB; PA134905167; -.
DR   VEuPathDB; HostDB:ENSG00000180083; -.
DR   eggNOG; ENOG502TE8U; Eukaryota.
DR   GeneTree; ENSGT00940000163115; -.
DR   HOGENOM; CLU_191873_0_0_1; -.
DR   InParanoid; Q8NEX6; -.
DR   OMA; CGNICWE; -.
DR   OrthoDB; 1531872at2759; -.
DR   PhylomeDB; Q8NEX6; -.
DR   TreeFam; TF338513; -.
DR   PathwayCommons; Q8NEX6; -.
DR   BioGRID-ORCS; 259239; 13 hits in 989 CRISPR screens.
DR   ChiTaRS; WFDC11; human.
DR   GenomeRNAi; 259239; -.
DR   Pharos; Q8NEX6; Tdark.
DR   PRO; PR:Q8NEX6; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q8NEX6; protein.
DR   Bgee; ENSG00000180083; Expressed in corpus epididymis and 60 other tissues.
DR   Genevisible; Q8NEX6; HS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   InterPro; IPR020310; WFDC11.
DR   PANTHER; PTHR19441:SF12; PTHR19441:SF12; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..87
FT                   /note="Protein WFDC11"
FT                   /id="PRO_0000041389"
SQ   SEQUENCE   87 AA;  10340 MW;  A9444227D9065F25 CRC64;
     MVSLMKLWIP MLMTFFCTVL LSVLGEMRKK RYDRKELLLE ECWGKPNVKE CTNKCSKAFR
     CKDKNYTCCW TYCGNICWIN VETSGDY