WFD13_HUMAN
ID WFD13_HUMAN Reviewed; 93 AA.
AC Q8IUB5; Q5TEU7; Q8WWK7;
DT 04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=WAP four-disulfide core domain protein 13;
DE Flags: Precursor;
GN Name=WFDC13; Synonyms=C20orf138, WAP13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12206714; DOI=10.1042/bj20020869;
RA Clauss A., Lilja H., Lundwall A.;
RT "A locus on human chromosome 20 contains several genes expressing protease
RT inhibitor domains with homology to whey acidic protein.";
RL Biochem. J. 368:233-242(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- FUNCTION: Putative acid-stable proteinase inhibitor. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8IUB5; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12041955, EBI-16439278;
CC Q8IUB5; O43765: SGTA; NbExp=5; IntAct=EBI-12041955, EBI-347996;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AF454505; AAN70988.1; -; mRNA.
DR EMBL; AL109656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS13367.1; -.
DR RefSeq; NP_742002.1; NM_172005.1.
DR AlphaFoldDB; Q8IUB5; -.
DR SMR; Q8IUB5; -.
DR BioGRID; 127891; 2.
DR IntAct; Q8IUB5; 2.
DR STRING; 9606.ENSP00000302938; -.
DR BioMuta; WFDC13; -.
DR DMDM; 29611896; -.
DR MassIVE; Q8IUB5; -.
DR PaxDb; Q8IUB5; -.
DR PeptideAtlas; Q8IUB5; -.
DR PRIDE; Q8IUB5; -.
DR ProteomicsDB; 70537; -.
DR DNASU; 164237; -.
DR Ensembl; ENST00000305479.3; ENSP00000302938.2; ENSG00000168634.5.
DR GeneID; 164237; -.
DR KEGG; hsa:164237; -.
DR MANE-Select; ENST00000305479.3; ENSP00000302938.2; NM_172005.2; NP_742002.1.
DR UCSC; uc002xpd.3; human.
DR CTD; 164237; -.
DR GeneCards; WFDC13; -.
DR HGNC; HGNC:16131; WFDC13.
DR HPA; ENSG00000168634; Tissue enriched (epididymis).
DR neXtProt; NX_Q8IUB5; -.
DR OpenTargets; ENSG00000168634; -.
DR PharmGKB; PA25680; -.
DR VEuPathDB; HostDB:ENSG00000168634; -.
DR eggNOG; KOG4295; Eukaryota.
DR GeneTree; ENSGT00390000012268; -.
DR HOGENOM; CLU_2612246_0_0_1; -.
DR InParanoid; Q8IUB5; -.
DR OMA; PPCRSEP; -.
DR OrthoDB; 1615189at2759; -.
DR PhylomeDB; Q8IUB5; -.
DR TreeFam; TF341262; -.
DR PathwayCommons; Q8IUB5; -.
DR SignaLink; Q8IUB5; -.
DR BioGRID-ORCS; 164237; 27 hits in 1052 CRISPR screens.
DR GenomeRNAi; 164237; -.
DR Pharos; Q8IUB5; Tdark.
DR PRO; PR:Q8IUB5; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8IUB5; protein.
DR Bgee; ENSG00000168634; Expressed in cauda epididymis and 51 other tissues.
DR Genevisible; Q8IUB5; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR InterPro; IPR029720; WFDC13.
DR PANTHER; PTHR19441:SF22; PTHR19441:SF22; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..93
FT /note="WAP four-disulfide core domain protein 13"
FT /id="PRO_0000041393"
FT DOMAIN 24..73
FT /note="WAP; atypical"
FT DISULFID 45..66
FT /evidence="ECO:0000250"
FT DISULFID 49..61
FT /evidence="ECO:0000250"
FT DISULFID 55..70
FT /evidence="ECO:0000250"
SQ SEQUENCE 93 AA; 10386 MW; 048B1B94E8F75910 CRC64;
MKPVLPLQFL VVFCLALQLV PGSPKQRVLK YILEPPPCIS APENCTHLCT MQEDCEKGFQ
CCSSFCGIVC SSETFQKRNR IKHKGSEVIM PAN
