WFD13_MOUSE
ID WFD13_MOUSE Reviewed; 81 AA.
AC Q5DQQ6; Q6IE33;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=WAP four-disulfide core domain protein 13;
DE AltName: Full=WAP four-disulfide core domain 13-like 1;
DE Flags: Precursor;
GN Name=Wfdc13; Synonyms=Wfdc13l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15950183; DOI=10.1016/j.bbrc.2005.05.125;
RA Clauss A., Lilja H., Lundwall A.;
RT "The evolution of a genetic locus encoding small serine proteinase
RT inhibitors.";
RL Biochem. Biophys. Res. Commun. 333:383-389(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=15060002; DOI=10.1101/gr.1946304;
RA Puente X.S., Lopez-Otin C.;
RT "A genomic analysis of rat proteases and protease inhibitors.";
RL Genome Res. 14:609-622(2004).
CC -!- FUNCTION: Putative acid-stable proteinase inhibitor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AY542486; AAT27474.1; -; mRNA.
DR EMBL; AY542487; AAT27475.1; -; mRNA.
DR EMBL; AL591127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC145778; AAI45779.1; -; mRNA.
DR EMBL; BC145780; AAI45781.1; -; mRNA.
DR EMBL; BN000360; CAE51412.1; -; mRNA.
DR CCDS; CCDS38327.1; -.
DR RefSeq; NP_001012722.1; NM_001012704.1.
DR AlphaFoldDB; Q5DQQ6; -.
DR SMR; Q5DQQ6; -.
DR STRING; 10090.ENSMUSP00000085594; -.
DR PaxDb; Q5DQQ6; -.
DR PRIDE; Q5DQQ6; -.
DR ProteomicsDB; 297845; -.
DR DNASU; 408190; -.
DR Ensembl; ENSMUST00000088260; ENSMUSP00000085594; ENSMUSG00000067704.
DR GeneID; 408190; -.
DR KEGG; mmu:408190; -.
DR UCSC; uc008nvq.1; mouse.
DR CTD; 164237; -.
DR MGI; MGI:3582777; Wfdc13.
DR VEuPathDB; HostDB:ENSMUSG00000067704; -.
DR eggNOG; KOG4295; Eukaryota.
DR GeneTree; ENSGT00390000012268; -.
DR HOGENOM; CLU_2612246_0_0_1; -.
DR InParanoid; Q5DQQ6; -.
DR OMA; PPCRSEP; -.
DR OrthoDB; 1615189at2759; -.
DR PhylomeDB; Q5DQQ6; -.
DR TreeFam; TF341262; -.
DR BioGRID-ORCS; 408190; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q5DQQ6; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q5DQQ6; protein.
DR Bgee; ENSMUSG00000067704; Expressed in epiblast (generic) and 10 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR InterPro; IPR029720; WFDC13.
DR PANTHER; PTHR19441:SF22; PTHR19441:SF22; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Protease inhibitor; Reference proteome; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..81
FT /note="WAP four-disulfide core domain protein 13"
FT /id="PRO_0000415848"
FT DOMAIN 31..74
FT /note="WAP"
FT DISULFID 38..62
FT /evidence="ECO:0000250"
FT DISULFID 45..66
FT /evidence="ECO:0000250"
FT DISULFID 49..61
FT /evidence="ECO:0000250"
FT DISULFID 55..70
FT /evidence="ECO:0000250"
SQ SEQUENCE 81 AA; 8798 MW; 9457C098097796E9 CRC64;
MRPVSPLQLL LVLSLAPQPV LGSPKQYFLK YILEPPPCRS EPGACNMFCT QQEECPEPLQ
CCSAYCGIVC TSNQAPVLGL S
