ID   WFD18_BOVIN             Reviewed;          74 AA.
AC   P62811; Q62477;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=WAP four-disulfide core domain protein 18;
DE   AltName: Full=Extracellular peptidase inhibitor;
DE   AltName: Full=Protein WDNM1;
DE   Flags: Precursor;
GN   Name=WFDC18; Synonyms=EXPI, WDNM1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RA   Kho Y.J., Lee D.Y., Choi Y.J., Baik M.G.;
RT   "Cloning and characterization of involution specific genes in bovine
RT   mammary gland.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could have proteinase inhibiting capacity.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; AF159701; AAF76524.1; -; mRNA.
DR   AlphaFoldDB; P62811; -.
DR   SMR; P62811; -.
DR   MEROPS; I17.004; -.
DR   InParanoid; P62811; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   Gene3D; 4.10.75.10; -; 1.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   Pfam; PF00095; WAP; 1.
DR   PRINTS; PR00003; 4DISULPHCORE.
DR   SMART; SM00217; WAP; 1.
DR   SUPFAM; SSF57256; SSF57256; 1.
DR   PROSITE; PS51390; WAP; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..74
FT                   /note="WAP four-disulfide core domain protein 18"
FT                   /id="PRO_0000041375"
FT   DOMAIN          26..73
FT                   /note="WAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ   SEQUENCE   74 AA;  7787 MW;  42BDCAD5B330B3D3 CRC64;
     MKTATVFVLV ALIFMTMTTA WALSNPKEKP GACPKPPPRS FGTCDERCTG DGSCSGNMKC
     CSNGCGHACK PPVF