WFD18_MOUSE
ID WFD18_MOUSE Reviewed; 74 AA.
AC P62810; Q62477; Q91VQ6;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=WAP four-disulfide core domain protein 18;
DE AltName: Full=Extracellular peptidase inhibitor;
DE AltName: Full=Protein WDNM1;
DE Flags: Precursor;
GN Name=Wfdc18; Synonyms=Expi, Wdnm1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=7970700;
RA Morrison B.W., Leder P.;
RT "neu and ras initiate murine mammary tumors that share genetic markers
RT generally absent in c-myc and int-2-initiated tumors.";
RL Oncogene 9:3417-3426(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could have proteinase inhibiting capacity.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; X93037; CAA63605.1; -; mRNA.
DR EMBL; BC010986; AAH10986.1; -; mRNA.
DR CCDS; CCDS25175.1; -.
DR PIR; S61553; S61553.
DR RefSeq; NP_031995.3; NM_007969.4.
DR AlphaFoldDB; P62810; -.
DR SMR; P62810; -.
DR STRING; 10090.ENSMUSP00000001009; -.
DR MEROPS; I17.004; -.
DR PaxDb; P62810; -.
DR PRIDE; P62810; -.
DR ProteomicsDB; 297557; -.
DR DNASU; 14038; -.
DR Ensembl; ENSMUST00000001009; ENSMUSP00000001009; ENSMUSG00000000983.
DR GeneID; 14038; -.
DR KEGG; mmu:14038; -.
DR UCSC; uc007kpr.1; mouse.
DR CTD; 14038; -.
DR MGI; MGI:107506; Wfdc18.
DR VEuPathDB; HostDB:ENSMUSG00000000983; -.
DR eggNOG; ENOG502RXHY; Eukaryota.
DR GeneTree; ENSGT00530000064879; -.
DR HOGENOM; CLU_2637440_0_0_1; -.
DR InParanoid; P62810; -.
DR OMA; VFGICAE; -.
DR OrthoDB; 1552779at2759; -.
DR PhylomeDB; P62810; -.
DR BioGRID-ORCS; 14038; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Wfdc18; mouse.
DR PRO; PR:P62810; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P62810; protein.
DR Bgee; ENSMUSG00000000983; Expressed in lacrimal gland and 87 other tissues.
DR ExpressionAtlas; P62810; baseline and differential.
DR Genevisible; P62810; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 4.10.75.10; -; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 1.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57256; SSF57256; 1.
DR PROSITE; PS51390; WAP; 1.
PE 3: Inferred from homology;
KW Protease inhibitor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..74
FT /note="WAP four-disulfide core domain protein 18"
FT /id="PRO_0000041376"
FT DOMAIN 26..73
FT /note="WAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT CONFLICT 47
FT /note="R -> Q (in Ref. 2; AAH10986)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 74 AA; 7787 MW; 42BDCAD5B330B3D3 CRC64;
MKTATVFVLV ALIFMTMTTA WALSNPKEKP GACPKPPPRS FGTCDERCTG DGSCSGNMKC
CSNGCGHACK PPVF
