ID   WFD18_RAT               Reviewed;          74 AA.
AC   P14730;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=WAP four-disulfide core domain protein 18;
DE   AltName: Full=Extracellular peptidase inhibitor;
DE   AltName: Full=Protein WDNM1;
DE   Flags: Precursor; Fragment;
GN   Name=Wfdc18; Synonyms=Expi, Wdnm1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary carcinoma;
RX   PubMed=3136918;
RA   Dear T.N., Ramshaw I.A., Kefford R.F.;
RT   "Differential expression of a novel gene, WDNM1, in nonmetastatic rat
RT   mammary adenocarcinoma cells.";
RL   Cancer Res. 48:5203-5209(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Thymus;
RX   PubMed=2018519; DOI=10.1016/0006-291x(91)90916-u;
RA   Dear T.N., Kefford R.F.;
RT   "The WDNM1 gene product is a novel member of the 'four-disulphide core'
RT   family of proteins.";
RL   Biochem. Biophys. Res. Commun. 176:247-254(1991).
CC   -!- FUNCTION: Involved in the metastatic potential of adenocarcinomas in
CC       rat. Could have proteinase inhibiting capacity.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Spleen, kidney, brain, liver, lung and cell line
CC       Rat-2.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA31688.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; X13309; CAA31688.1; ALT_INIT; mRNA.
DR   PIR; S07807; S07807.
DR   AlphaFoldDB; P14730; -.
DR   SMR; P14730; -.
DR   STRING; 10116.ENSRNOP00000052774; -.
DR   MEROPS; I17.004; -.
DR   PaxDb; P14730; -.
DR   PRIDE; P14730; -.
DR   RGD; 619957; Wfdc18.
DR   eggNOG; ENOG502RXHY; Eukaryota.
DR   InParanoid; P14730; -.
DR   PhylomeDB; P14730; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   Gene3D; 4.10.75.10; -; 1.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   Pfam; PF00095; WAP; 1.
DR   PRINTS; PR00003; 4DISULPHCORE.
DR   SMART; SM00217; WAP; 1.
DR   SUPFAM; SSF57256; SSF57256; 1.
DR   PROSITE; PS51390; WAP; 1.
PE   2: Evidence at transcript level;
KW   Protease inhibitor; Reference proteome; Secreted; Signal.
FT   SIGNAL          <1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..74
FT                   /note="WAP four-disulfide core domain protein 18"
FT                   /id="PRO_0000041377"
FT   DOMAIN          26..73
FT                   /note="WAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   NON_TER         1
SQ   SEQUENCE   74 AA;  7740 MW;  51802C70CDAF0521 CRC64;
     TASVLLLVAL IAVGMNITYA LFSPTKLEKP GKCPKNPPRS IGTCVELCSG DQSCPNIQKC
     CSNGCGHVCK SPVF