WFD21_MOUSE
ID WFD21_MOUSE Reviewed; 63 AA.
AC Q8BTE6;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein Wfdc21 {ECO:0000305};
DE AltName: Full=Wdnm1-like protein {ECO:0000303|PubMed:18492766};
DE Flags: Precursor;
GN Name=Wfdc21 {ECO:0000312|MGI:MGI:1913357};
GN Synonyms=Wdnml1 {ECO:0000303|PubMed:18492766};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAC25022.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:EDL15719.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=18492766; DOI=10.1152/ajpendo.90316.2008;
RA Wu Y., Smas C.M.;
RT "Wdnm1-like, a new adipokine with a role in MMP-2 activation.";
RL Am. J. Physiol. 295:E205-215(2008).
CC -!- FUNCTION: May promote activation of the metalloproteinase MMP2.
CC {ECO:0000269|PubMed:18492766}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18492766}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in white adipose tissue and
CC liver. {ECO:0000269|PubMed:18492766}.
CC -!- INDUCTION: Up-regulated by TNF-alpha and lipopolysaccharide (LPS) in
CC vitro. {ECO:0000269|PubMed:18492766}.
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DR EMBL; AK003164; BAC25022.1; -; mRNA.
DR EMBL; AL663075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466556; EDL15719.1; -; Genomic_DNA.
DR CCDS; CCDS36258.1; -.
DR RefSeq; NP_899072.1; NM_183249.2.
DR AlphaFoldDB; Q8BTE6; -.
DR SMR; Q8BTE6; -.
DR STRING; 10090.ENSMUSP00000064479; -.
DR MaxQB; Q8BTE6; -.
DR PaxDb; Q8BTE6; -.
DR PeptideAtlas; Q8BTE6; -.
DR PRIDE; Q8BTE6; -.
DR ProteomicsDB; 299671; -.
DR Ensembl; ENSMUST00000070832; ENSMUSP00000064479; ENSMUSG00000051748.
DR GeneID; 66107; -.
DR KEGG; mmu:66107; -.
DR UCSC; uc007kps.1; mouse.
DR CTD; 66107; -.
DR MGI; MGI:1913357; Wfdc21.
DR VEuPathDB; HostDB:ENSMUSG00000051748; -.
DR eggNOG; ENOG502TDX4; Eukaryota.
DR GeneTree; ENSGT00520000060616; -.
DR HOGENOM; CLU_2885048_0_0_1; -.
DR InParanoid; Q8BTE6; -.
DR OMA; DCDLGER; -.
DR OrthoDB; 1624852at2759; -.
DR PhylomeDB; Q8BTE6; -.
DR BioGRID-ORCS; 66107; 2 hits in 68 CRISPR screens.
DR ChiTaRS; Wfdc21; mouse.
DR PRO; PR:Q8BTE6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BTE6; protein.
DR Bgee; ENSMUSG00000051748; Expressed in granulocyte and 91 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0008047; F:enzyme activator activity; IDA:MGI.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0032496; P:response to lipopolysaccharide; IDA:MGI.
DR GO; GO:0034612; P:response to tumor necrosis factor; IDA:MGI.
DR GO; GO:0050872; P:white fat cell differentiation; IDA:MGI.
DR Gene3D; 4.10.75.10; -; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 1.
DR SUPFAM; SSF57256; SSF57256; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..63
FT /note="Protein Wfdc21"
FT /id="PRO_5005940237"
FT DOMAIN 25..63
FT /note="WAP; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 35..56
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 39..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 45..60
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 63 AA; 6792 MW; A9E69DCE3C825C02 CRC64;
MKLGAFLLLV SLITLSLEVQ ELQAAVRPLQ LLGTCAELCR GDWDCGPEEQ CVSIGCSHIC
TTN
