ID   WFDC1_CHICK             Reviewed;         222 AA.
AC   Q8JG33;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=WAP four-disulfide core domain protein 1;
DE   AltName: Full=Protein ps20;
DE   Flags: Precursor;
GN   Name=WFDC1; Synonyms=PS20;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lopez-Viado C., Galetto R., Piedra E., Ros M., Rodriguez-Rey J.C.;
RT   "cps20 is differentially expressed in chicken limb buds.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has growth inhibitory activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; AJ438290; CAD27352.1; -; mRNA.
DR   RefSeq; NP_989885.1; NM_204554.1.
DR   AlphaFoldDB; Q8JG33; -.
DR   SMR; Q8JG33; -.
DR   STRING; 9031.ENSGALP00000008818; -.
DR   PaxDb; Q8JG33; -.
DR   Ensembl; ENSGALT00000008832; ENSGALP00000008818; ENSGALG00000005503.
DR   Ensembl; ENSGALT00000091379; ENSGALP00000068024; ENSGALG00000005503.
DR   GeneID; 395238; -.
DR   KEGG; gga:395238; -.
DR   CTD; 58189; -.
DR   VEuPathDB; HostDB:geneid_395238; -.
DR   eggNOG; ENOG502QWDC; Eukaryota.
DR   GeneTree; ENSGT00390000014299; -.
DR   HOGENOM; CLU_108761_0_0_1; -.
DR   InParanoid; Q8JG33; -.
DR   OMA; DGHNLRH; -.
DR   OrthoDB; 1614363at2759; -.
DR   PhylomeDB; Q8JG33; -.
DR   TreeFam; TF328768; -.
DR   PRO; PR:Q8JG33; -.
DR   Proteomes; UP000000539; Chromosome 11.
DR   Bgee; ENSGALG00000005503; Expressed in lung and 9 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0061045; P:negative regulation of wound healing; IEA:Ensembl.
DR   GO; GO:0001558; P:regulation of cell growth; IBA:GO_Central.
DR   Gene3D; 4.10.75.10; -; 1.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   InterPro; IPR042357; WFDC1.
DR   PANTHER; PTHR14308; PTHR14308; 1.
DR   Pfam; PF00095; WAP; 1.
DR   SMART; SM00217; WAP; 1.
DR   SUPFAM; SSF57256; SSF57256; 1.
DR   PROSITE; PS51390; WAP; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..222
FT                   /note="WAP four-disulfide core domain protein 1"
FT                   /id="PRO_0000041368"
FT   DOMAIN          61..110
FT                   /note="WAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        68..98
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        80..102
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        85..97
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        91..106
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ   SEQUENCE   222 AA;  25236 MW;  CD8B00BD1CED5BEB CRC64;
     MDSRMLSDQR FCRRIFAAAL CVLVLLADSG CARNLWKRAL HLKMTEKYDD YEYPLHSHSA
     HYQKNDRCPP PPQTLPDRAC EVPSCRSDSE CERHKRCCYN GCIYACLESV QPPPVLDWLV
     QPKPRWLGGN GWLLDGPEEV LQAEACSTTE DGDEPLHCPT GYECHIINPG NTAEGIPNRG
     QCIKLRGNPD GRNLRHKYYK EYFGSNSNNV VGYVKNQQKH LG