ID   WFDC1_MOUSE             Reviewed;         211 AA.
AC   Q9ESH5; Q8R110;
DT   02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=WAP four-disulfide core domain protein 1;
DE   AltName: Full=Prostate stromal protein ps20;
DE   AltName: Full=ps20 growth inhibitor;
DE   Flags: Precursor;
GN   Name=Wfdc1; Synonyms=Ps20;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/SvJ;
RX   PubMed=10967136; DOI=10.1007/s003350010135;
RA   Larsen M., Ressler S.J., Gerdes M.J., Lu B., Byron M., Lawrence J.B.,
RA   Rowley D.R.;
RT   "The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in
RT   multiple cancers.";
RL   Mamm. Genome 11:767-773(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-211.
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Has growth inhibitory activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; AF170446; AAG21086.1; -; Genomic_DNA.
DR   EMBL; AF169632; AAG21086.1; JOINED; Genomic_DNA.
DR   EMBL; BC025850; AAH25850.1; -; mRNA.
DR   CCDS; CCDS22711.1; -.
DR   RefSeq; NP_075884.1; NM_023395.2.
DR   AlphaFoldDB; Q9ESH5; -.
DR   SMR; Q9ESH5; -.
DR   STRING; 10090.ENSMUSP00000024107; -.
DR   MEROPS; I17.004; -.
DR   PhosphoSitePlus; Q9ESH5; -.
DR   MaxQB; Q9ESH5; -.
DR   PaxDb; Q9ESH5; -.
DR   PRIDE; Q9ESH5; -.
DR   ProteomicsDB; 299672; -.
DR   Antibodypedia; 30582; 180 antibodies from 29 providers.
DR   DNASU; 67866; -.
DR   Ensembl; ENSMUST00000024107; ENSMUSP00000024107; ENSMUSG00000023336.
DR   GeneID; 67866; -.
DR   KEGG; mmu:67866; -.
DR   UCSC; uc009nqe.1; mouse.
DR   CTD; 58189; -.
DR   MGI; MGI:1915116; Wfdc1.
DR   VEuPathDB; HostDB:ENSMUSG00000023336; -.
DR   eggNOG; ENOG502QWDC; Eukaryota.
DR   GeneTree; ENSGT00390000014299; -.
DR   HOGENOM; CLU_108761_0_0_1; -.
DR   InParanoid; Q9ESH5; -.
DR   OMA; DGHNLRH; -.
DR   OrthoDB; 1614363at2759; -.
DR   PhylomeDB; Q9ESH5; -.
DR   TreeFam; TF328768; -.
DR   BioGRID-ORCS; 67866; 0 hits in 71 CRISPR screens.
DR   PRO; PR:Q9ESH5; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q9ESH5; protein.
DR   Bgee; ENSMUSG00000023336; Expressed in temporalis muscle and 123 other tissues.
DR   ExpressionAtlas; Q9ESH5; baseline and differential.
DR   Genevisible; Q9ESH5; MM.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:MGI.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
DR   GO; GO:0061045; P:negative regulation of wound healing; IMP:MGI.
DR   GO; GO:0001558; P:regulation of cell growth; ISO:MGI.
DR   Gene3D; 4.10.75.10; -; 1.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   InterPro; IPR042357; WFDC1.
DR   PANTHER; PTHR14308; PTHR14308; 1.
DR   Pfam; PF00095; WAP; 1.
DR   SMART; SM00217; WAP; 1.
DR   SUPFAM; SSF57256; SSF57256; 1.
DR   PROSITE; PS51390; WAP; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Protease inhibitor; Reference proteome; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..211
FT                   /note="WAP four-disulfide core domain protein 1"
FT                   /id="PRO_0000041366"
FT   DOMAIN          50..99
FT                   /note="WAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   REGION          182..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        57..87
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        69..91
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        74..86
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        80..95
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   CONFLICT        132
FT                   /note="Missing (in Ref. 2; AAH25850)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   211 AA;  23079 MW;  605E7E6B0FC64FE5 CRC64;
     MGNCGRKVLR ALSFLLLLGS SSAQGTWEAM LPARLAEKSR AEEVAATGSR QPHADRCPPP
     PRTLPPGACQ ATRCQADSEC PRHRRCCYNG CAYACLEAVP PPPVLDWLVQ PKPRWLGGNG
     WLLDGPEEVL QAETCSTTED GAEPLLCPSG YECHILQPGD EAQGIPNHGQ CVKQRRQAEG
     RVLRQRLHKE YPEGDSKNVA EPGKGQQRHF P