WFDC1_RAT
ID WFDC1_RAT Reviewed; 212 AA.
AC O70280;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=WAP four-disulfide core domain protein 1;
DE AltName: Full=Prostate stromal protein ps20;
DE AltName: Full=ps20 growth inhibitor;
DE Flags: Precursor;
GN Name=Wfdc1; Synonyms=Ps20;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Prostate;
RX PubMed=9468514; DOI=10.1074/jbc.273.8.4574;
RA Larsen M., Ressler S.J., Lu B., Gerdes M.J., McBride L., Dang T.D.,
RA Rowley D.R.;
RT "Molecular cloning and expression of ps20 growth inhibitor. A novel WAP-
RT type 'four-disulfide core' domain protein expressed in smooth muscle.";
RL J. Biol. Chem. 273:4574-4584(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 27-54, AND CHARACTERIZATION.
RX PubMed=7665628; DOI=10.1074/jbc.270.37.22058;
RA Rowley D.R., Dang T.D., Larsen M., Gerdes M.J., McBride L., Lu B.;
RT "Purification of a novel protein (ps20) from urogenital sinus mesenchymal
RT cells with growth inhibitory properties in vitro.";
RL J. Biol. Chem. 270:22058-22065(1995).
CC -!- FUNCTION: Has growth inhibitory activity.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Vascular smooth muscle and prostate. Periacinar
CC ring.
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DR EMBL; AF037272; AAC40055.1; -; mRNA.
DR EMBL; BC063152; AAH63152.1; -; mRNA.
DR RefSeq; NP_598265.1; NM_133581.1.
DR RefSeq; XP_006255767.1; XM_006255705.2.
DR AlphaFoldDB; O70280; -.
DR SMR; O70280; -.
DR STRING; 10116.ENSRNOP00000021630; -.
DR MEROPS; I17.004; -.
DR PaxDb; O70280; -.
DR GeneID; 171112; -.
DR KEGG; rno:171112; -.
DR UCSC; RGD:68938; rat.
DR CTD; 58189; -.
DR RGD; 68938; Wfdc1.
DR VEuPathDB; HostDB:ENSRNOG00000015904; -.
DR eggNOG; ENOG502QWDC; Eukaryota.
DR HOGENOM; CLU_108761_0_0_1; -.
DR InParanoid; O70280; -.
DR OMA; DGHNLRH; -.
DR OrthoDB; 1614363at2759; -.
DR PhylomeDB; O70280; -.
DR TreeFam; TF328768; -.
DR PRO; PR:O70280; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Bgee; ENSRNOG00000015904; Expressed in heart and 19 other tissues.
DR Genevisible; O70280; RN.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:RGD.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
DR GO; GO:0061045; P:negative regulation of wound healing; ISO:RGD.
DR GO; GO:0001558; P:regulation of cell growth; IDA:RGD.
DR GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR Gene3D; 4.10.75.10; -; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR InterPro; IPR042357; WFDC1.
DR PANTHER; PTHR14308; PTHR14308; 1.
DR Pfam; PF00095; WAP; 1.
DR SMART; SM00217; WAP; 1.
DR SUPFAM; SSF57256; SSF57256; 1.
DR PROSITE; PS51390; WAP; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Protease inhibitor;
KW Reference proteome; Secreted; Serine protease inhibitor; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000269|PubMed:7665628"
FT CHAIN 27..212
FT /note="WAP four-disulfide core domain protein 1"
FT /id="PRO_0000041367"
FT DOMAIN 51..100
FT /note="WAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT REGION 43..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 58..88
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 70..92
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 75..87
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 81..96
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 212 AA; 23230 MW; 2BB054DE9D8460A5 CRC64;
MGSCDRKALW ALSFLLLLLG SSSVQGTWEA MLPVRLAEKS QAEEVAATGS RQPHADRCPP
PPRTLPPGAC QATRCQSDSE CPRHRRCCYN GCAYACLEAV PPPPVLDWLV QPKPRWLGGN
GWLLDGPEEV LQAEACSTTE DGAEPLLCPS GYECHILQPG DAAQGIPNHG RCVKQRRQAE
GRVLRQKLHK EYPEGDSKYV AEPGKGQQRH FP
