WFDC2_PIG
ID WFDC2_PIG Reviewed; 123 AA.
AC Q8MI69;
DT 27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=WAP four-disulfide core domain protein 2;
DE AltName: Full=Epididymal secretory protein E4;
DE Flags: Precursor;
GN Name=WFDC2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Epididymis;
RX PubMed=12654021; DOI=10.1046/j.1439-0531.2003.00403.x;
RA Schaefer B., von Horsten H.H., Dacheux J.-L., Holtz W., Kirchhoff C.;
RT "Cloning and characterization of boar epididymal secretory proteins by
RT homology to the human.";
RL Reprod. Domest. Anim. 38:111-118(2003).
CC -!- FUNCTION: Broad range protease inhibitor. {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Detected in the distal parts of the epididymis.
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DR EMBL; AJ506744; CAD44844.1; -; mRNA.
DR RefSeq; NP_999112.1; NM_213947.1.
DR RefSeq; XP_013840883.1; XM_013985429.1.
DR AlphaFoldDB; Q8MI69; -.
DR SMR; Q8MI69; -.
DR STRING; 9823.ENSSSCP00000007889; -.
DR MEROPS; I17.004; -.
DR PaxDb; Q8MI69; -.
DR Ensembl; ENSSSCT00000039535; ENSSSCP00000034464; ENSSSCG00000033003.
DR GeneID; 396987; -.
DR KEGG; ssc:396987; -.
DR CTD; 10406; -.
DR VGNC; VGNC:95719; WFDC2.
DR eggNOG; ENOG502SA8J; Eukaryota.
DR GeneTree; ENSGT00730000111410; -.
DR HOGENOM; CLU_187014_0_0_1; -.
DR InParanoid; Q8MI69; -.
DR OMA; NEKQGSC; -.
DR OrthoDB; 1409658at2759; -.
DR Proteomes; UP000008227; Chromosome 17.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000033003; Expressed in penis and 36 other tissues.
DR Genevisible; Q8MI69; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019828; F:aspartic-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 4.10.75.10; -; 2.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 2.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 2.
DR SUPFAM; SSF57256; SSF57256; 2.
DR PROSITE; PS51390; WAP; 2.
PE 2: Evidence at transcript level;
KW Aspartic protease inhibitor; Disulfide bond; Protease inhibitor;
KW Reference proteome; Repeat; Secreted; Serine protease inhibitor; Signal;
KW Thiol protease inhibitor.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..123
FT /note="WAP four-disulfide core domain protein 2"
FT /id="PRO_0000041372"
FT DOMAIN 28..69
FT /note="WAP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 72..122
FT /note="WAP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 35..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 44..65
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 48..60
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 54..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 79..109
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 92..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 96..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 102..118
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 123 AA; 12756 MW; 2CE8431D72AB14EC CRC64;
MPACRLGLLV ASLLLGLLLG LPPVTGTGAE KSGVCPAVEV DMNCTQECLS DADCADNLKC
CKAGCVTICQ MPNEKEGSCP QVDIAFPQLG LCLDQCQVDS QCPGQLKCCR NGCGKVSCVT
PVF
