WFDC3_HUMAN
ID WFDC3_HUMAN Reviewed; 231 AA.
AC Q8IUB2; A6PVF2; Q0P6A5; Q3T1C5; Q8TC52; Q9BQP3; Q9BQP4;
DT 27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=WAP four-disulfide core domain protein 3;
DE AltName: Full=Putative protease inhibitor WAP14;
DE Flags: Precursor;
GN Name=WFDC3; Synonyms=WAP14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12206714; DOI=10.1042/bj20020869;
RA Clauss A., Lilja H., Lundwall A.;
RT "A locus on human chromosome 20 contains several genes expressing protease
RT inhibitor domains with homology to whey acidic protein.";
RL Biochem. J. 368:233-242(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-231.
RA Stavrides G.S., Huckle E.J., Deloukas P.;
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-231.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8IUB2; O43681: GET3; NbExp=3; IntAct=EBI-7963932, EBI-2515857;
CC Q8IUB2; Q5T754: LCE1F; NbExp=3; IntAct=EBI-7963932, EBI-11958008;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI02014.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI02015.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF488306; AAN70993.1; -; mRNA.
DR EMBL; AL050348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL591713; CAC39444.1; -; mRNA.
DR EMBL; BC102013; AAI02014.1; ALT_INIT; mRNA.
DR EMBL; BC102014; AAI02015.1; ALT_INIT; mRNA.
DR CCDS; CCDS33478.1; -.
DR RefSeq; NP_542181.1; NM_080614.1.
DR AlphaFoldDB; Q8IUB2; -.
DR SMR; Q8IUB2; -.
DR BioGRID; 126649; 5.
DR IntAct; Q8IUB2; 3.
DR MINT; Q8IUB2; -.
DR STRING; 9606.ENSP00000243938; -.
DR MEROPS; I17.001; -.
DR GlyGen; Q8IUB2; 2 sites.
DR BioMuta; WFDC3; -.
DR DMDM; 32363334; -.
DR PaxDb; Q8IUB2; -.
DR PeptideAtlas; Q8IUB2; -.
DR PRIDE; Q8IUB2; -.
DR ProteomicsDB; 70534; -.
DR Antibodypedia; 59149; 22 antibodies from 13 providers.
DR DNASU; 140686; -.
DR Ensembl; ENST00000243938.9; ENSP00000243938.4; ENSG00000124116.19.
DR GeneID; 140686; -.
DR KEGG; hsa:140686; -.
DR MANE-Select; ENST00000243938.9; ENSP00000243938.4; NM_080614.2; NP_542181.1.
DR UCSC; uc002xpf.1; human.
DR CTD; 140686; -.
DR DisGeNET; 140686; -.
DR GeneCards; WFDC3; -.
DR HGNC; HGNC:15957; WFDC3.
DR HPA; ENSG00000124116; Group enriched (skin, testis).
DR neXtProt; NX_Q8IUB2; -.
DR OpenTargets; ENSG00000124116; -.
DR PharmGKB; PA38067; -.
DR VEuPathDB; HostDB:ENSG00000124116; -.
DR eggNOG; ENOG502S9BM; Eukaryota.
DR GeneTree; ENSGT00730000111454; -.
DR HOGENOM; CLU_105901_0_0_1; -.
DR InParanoid; Q8IUB2; -.
DR OMA; CRGDIPK; -.
DR OrthoDB; 1631923at2759; -.
DR PhylomeDB; Q8IUB2; -.
DR TreeFam; TF338375; -.
DR PathwayCommons; Q8IUB2; -.
DR SignaLink; Q8IUB2; -.
DR BioGRID-ORCS; 140686; 12 hits in 1063 CRISPR screens.
DR ChiTaRS; WFDC3; human.
DR GenomeRNAi; 140686; -.
DR Pharos; Q8IUB2; Tdark.
DR PRO; PR:Q8IUB2; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8IUB2; protein.
DR Bgee; ENSG00000124116; Expressed in sperm and 119 other tissues.
DR ExpressionAtlas; Q8IUB2; baseline and differential.
DR Genevisible; Q8IUB2; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 4.10.75.10; -; 4.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR InterPro; IPR029726; Wfdc3.
DR PANTHER; PTHR19441:SF46; PTHR19441:SF46; 2.
DR Pfam; PF00095; WAP; 4.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 4.
DR SUPFAM; SSF57256; SSF57256; 4.
DR PROSITE; PS51390; WAP; 4.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Protease inhibitor; Reference proteome;
KW Repeat; Secreted; Serine protease inhibitor; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..231
FT /note="WAP four-disulfide core domain protein 3"
FT /id="PRO_0000041381"
FT DOMAIN 26..68
FT /note="WAP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 69..114
FT /note="WAP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 119..162
FT /note="WAP 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 163..207
FT /note="WAP 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 217
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 33..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 40..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 44..56
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 50..65
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 76..102
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 85..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 89..101
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 95..110
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 126..150
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 133..154
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 137..149
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 143..158
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 170..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 178..199
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 182..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 188..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT VARIANT 36
FT /note="H -> D (in dbSNP:rs6032538)"
FT /id="VAR_052951"
FT VARIANT 198
FT /note="G -> S (in dbSNP:rs6073907)"
FT /id="VAR_059962"
FT CONFLICT 8..10
FT /note="LLK -> IKE (in Ref. 3; CAC39444)"
FT /evidence="ECO:0000305"
FT CONFLICT 26..28
FT /note="EHA -> RPS (in Ref. 4; AAI02014)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 231 AA; 24687 MW; 886B905654751DB3 CRC64;
MMLSCLFLLK ALLALGSLES WITAGEHAKE GECPPHKNPC KELCQGDELC PAEQKCCTTG
CGRICRDIPK GRKRDCPRVI RKQSCLKRCI TDETCPGVKK CCTLGCNKSC VVPISKQKLA
EFGGECPADP LPCEELCDGD ASCPQGHKCC STGCGRTCLG DIEGGRGGDC PKVLVGLCIV
GCVMDENCQA GEKCCKSGCG RFCVPPVLPP KLTMNPNWTV RSDSELEIPV P
