WFDC3_MOUSE
ID WFDC3_MOUSE Reviewed; 130 AA.
AC Q14AE4;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=WAP four-disulfide core domain protein 3;
DE AltName: Full=Putative protease inhibitor WAP14;
DE Flags: Precursor;
GN Name=Wfdc3; Synonyms=Wap14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AL591127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466551; EDL06411.1; -; Genomic_DNA.
DR EMBL; BC116847; AAI16848.1; -; mRNA.
DR EMBL; BC116875; AAI16876.1; -; mRNA.
DR CCDS; CCDS17053.1; -.
DR RefSeq; NP_082237.1; NM_027961.1.
DR RefSeq; XP_006500255.1; XM_006500192.2.
DR RefSeq; XP_006500256.1; XM_006500193.2.
DR RefSeq; XP_006500257.1; XM_006500194.3.
DR AlphaFoldDB; Q14AE4; -.
DR SMR; Q14AE4; -.
DR STRING; 10090.ENSMUSP00000099385; -.
DR GlyGen; Q14AE4; 1 site.
DR MaxQB; Q14AE4; -.
DR PaxDb; Q14AE4; -.
DR PeptideAtlas; Q14AE4; -.
DR PRIDE; Q14AE4; -.
DR ProteomicsDB; 299673; -.
DR Antibodypedia; 59149; 22 antibodies from 13 providers.
DR Ensembl; ENSMUST00000103096; ENSMUSP00000099385; ENSMUSG00000076434.
DR GeneID; 71856; -.
DR KEGG; mmu:71856; -.
DR UCSC; uc008nvt.1; mouse.
DR CTD; 140686; -.
DR MGI; MGI:1923897; Wfdc3.
DR VEuPathDB; HostDB:ENSMUSG00000076434; -.
DR eggNOG; ENOG502TB9A; Eukaryota.
DR GeneTree; ENSGT00730000111454; -.
DR HOGENOM; CLU_105901_1_0_1; -.
DR InParanoid; Q14AE4; -.
DR OMA; DANCEAG; -.
DR OrthoDB; 1631923at2759; -.
DR PhylomeDB; Q14AE4; -.
DR TreeFam; TF338375; -.
DR BioGRID-ORCS; 71856; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q14AE4; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q14AE4; protein.
DR Bgee; ENSMUSG00000076434; Expressed in morula and 70 other tissues.
DR ExpressionAtlas; Q14AE4; baseline and differential.
DR Genevisible; Q14AE4; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 4.10.75.10; -; 2.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR InterPro; IPR029726; Wfdc3.
DR PANTHER; PTHR19441:SF46; PTHR19441:SF46; 1.
DR Pfam; PF00095; WAP; 2.
DR SMART; SM00217; WAP; 2.
DR SUPFAM; SSF57256; SSF57256; 2.
DR PROSITE; PS51390; WAP; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Protease inhibitor; Reference proteome;
KW Repeat; Secreted; Serine protease inhibitor; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..130
FT /note="WAP four-disulfide core domain protein 3"
FT /id="PRO_0000415846"
FT DOMAIN 17..61
FT /note="WAP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 62..106
FT /note="WAP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 25..49
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 32..53
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 36..48
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 42..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 69..94
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 77..98
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 81..93
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 87..102
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 130 AA; 13718 MW; 517F6435D0D819BC CRC64;
MKALLALGFL ASWVAAGEHA LRGECPADPL PCQELCTGDE SCPQGHKCCS TGCGHACRGD
IEGGRDGQCP RILVGLCIVQ CMMDENCQSG ERCCKSGCGR FCIPGLQPLQ QLKDSNLTDG
FNSKLEAQAP
