WFDC5_AOTNA
ID WFDC5_AOTNA Reviewed; 123 AA.
AC A4K2W7;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=WAP four-disulfide core domain protein 5;
DE Flags: Precursor;
GN Name=WFDC5;
OS Aotus nancymaae (Ma's night monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC Aotus.
OX NCBI_TaxID=37293;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17267810; DOI=10.1101/gr.6004607;
RG NISC comparative sequencing program;
RA Hurle B., Swanson W., Green E.D.;
RT "Comparative sequence analyses reveal rapid and divergent evolutionary
RT changes of the WFDC locus in the primate lineage.";
RL Genome Res. 17:276-286(2007).
CC -!- FUNCTION: Putative acid-stable proteinase inhibitor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; DP000046; ABO53002.1; -; Genomic_DNA.
DR RefSeq; XP_012322690.1; XM_012467267.1.
DR AlphaFoldDB; A4K2W7; -.
DR SMR; A4K2W7; -.
DR STRING; 37293.ENSANAP00000010728; -.
DR GeneID; 105727445; -.
DR CTD; 149708; -.
DR OrthoDB; 1560605at2759; -.
DR Proteomes; UP000233020; Whole Genome Shotgun Assembly.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 4.10.75.10; -; 2.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 2.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 2.
DR SUPFAM; SSF57256; SSF57256; 2.
DR PROSITE; PS51390; WAP; 2.
PE 3: Inferred from homology;
KW Disulfide bond; Protease inhibitor; Reference proteome; Repeat; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..123
FT /note="WAP four-disulfide core domain protein 5"
FT /id="PRO_0000289633"
FT DOMAIN 27..73
FT /note="WAP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 74..121
FT /note="WAP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 34..62
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 41..66
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 49..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 55..70
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 81..109
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 88..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 96..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 102..117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 123 AA; 13368 MW; 35BCDE3FFC0312CF CRC64;
MRIQSLLLLG ALLAVGSQPP AAFGRKKGEK PGACPPDDGP CLLSVPDQCM EDRQCPLTRK
CCYRACFRQC VPRVSVKLGS CPEDQLRCLS PMNHLCHKDA DCSGKKRCCS SACGRDCRDP
VRG