WFDC5_MACMU
ID WFDC5_MACMU Reviewed; 123 AA.
AC A4K2T2;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=WAP four-disulfide core domain protein 5;
DE Flags: Precursor;
GN Name=WFDC5;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17267810; DOI=10.1101/gr.6004607;
RG NISC comparative sequencing program;
RA Hurle B., Swanson W., Green E.D.;
RT "Comparative sequence analyses reveal rapid and divergent evolutionary
RT changes of the WFDC locus in the primate lineage.";
RL Genome Res. 17:276-286(2007).
CC -!- FUNCTION: Putative acid-stable proteinase inhibitor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; DP000043; ABO52967.1; -; Genomic_DNA.
DR RefSeq; NP_001162157.1; NM_001168686.1.
DR AlphaFoldDB; A4K2T2; -.
DR SMR; A4K2T2; -.
DR STRING; 9544.ENSMMUP00000017363; -.
DR Ensembl; ENSMMUT00000018539; ENSMMUP00000017363; ENSMMUG00000013216.
DR GeneID; 711627; -.
DR KEGG; mcc:711627; -.
DR CTD; 149708; -.
DR VEuPathDB; HostDB:ENSMMUG00000013216; -.
DR VGNC; VGNC:108079; WFDC5.
DR eggNOG; ENOG502S99V; Eukaryota.
DR GeneTree; ENSGT00730000111369; -.
DR HOGENOM; CLU_105901_2_0_1; -.
DR InParanoid; A4K2T2; -.
DR OMA; KRCCPGA; -.
DR OrthoDB; 1560605at2759; -.
DR TreeFam; TF338375; -.
DR Proteomes; UP000006718; Chromosome 10.
DR Bgee; ENSMMUG00000013216; Expressed in fibroblast and 3 other tissues.
DR ExpressionAtlas; A4K2T2; baseline.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 4.10.75.10; -; 2.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 2.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 2.
DR SUPFAM; SSF57256; SSF57256; 2.
DR PROSITE; PS51390; WAP; 2.
PE 3: Inferred from homology;
KW Disulfide bond; Protease inhibitor; Reference proteome; Repeat; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..123
FT /note="WAP four-disulfide core domain protein 5"
FT /id="PRO_0000289639"
FT DOMAIN 27..73
FT /note="WAP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 74..121
FT /note="WAP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 34..62
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 41..66
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 49..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 55..70
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 81..109
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 88..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 96..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 102..117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 123 AA; 13395 MW; 586CB6C4B11BFB64 CRC64;
MRIQSLLLLG ALLAVGSQLP AVFGRKKGEK WGGCPADDGP CLLSVPDQCV EDSQCPLTRK
CCYRACFRQC IPRVSVKPGS CPQDQLRCLS PMNHLCHKDS DCSGKKRCCH SACGRDCRDP
ARG
