WFDC5_OTOGA
ID WFDC5_OTOGA Reviewed; 123 AA.
AC A4K2Q7;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 49.
DE RecName: Full=WAP four-disulfide core domain protein 5;
DE Flags: Precursor;
GN Name=WFDC5;
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=17267810; DOI=10.1101/gr.6004607;
RG NISC comparative sequencing program;
RA Hurle B., Swanson W., Green E.D.;
RT "Comparative sequence analyses reveal rapid and divergent evolutionary
RT changes of the WFDC locus in the primate lineage.";
RL Genome Res. 17:276-286(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii(Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative acid-stable proteinase inhibitor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; DP000040; ABO52942.1; -; Genomic_DNA.
DR AlphaFoldDB; A4K2Q7; -.
DR SMR; A4K2Q7; -.
DR STRING; 30611.ENSOGAP00000005962; -.
DR eggNOG; ENOG502S99V; Eukaryota.
DR InParanoid; A4K2Q7; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 4.10.75.10; -; 2.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00095; WAP; 2.
DR PRINTS; PR00003; 4DISULPHCORE.
DR SMART; SM00217; WAP; 2.
DR SUPFAM; SSF57256; SSF57256; 2.
DR PROSITE; PS51390; WAP; 2.
PE 3: Inferred from homology;
KW Disulfide bond; Protease inhibitor; Reference proteome; Repeat; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..123
FT /note="WAP four-disulfide core domain protein 5"
FT /id="PRO_0000289640"
FT DOMAIN 27..74
FT /note="WAP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 75..121
FT /note="WAP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 34..62
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 41..66
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 49..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 55..70
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 81..109
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 88..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 96..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DISULFID 102..117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ SEQUENCE 123 AA; 13213 MW; 19C2C281C0F67B37 CRC64;
MRFGRLLLLA VLLAGVSQLP AVSGRKKGEK PGGCPPDDGP CLLSVPDQCT DDSQCPSTMK
CCPRACFRQC IPRVSVKLGS CPVDQLHCLS PTKHLCHQDS NCSGKKRCCP TACGRDCRDP
VKE
