ID   WFDC5_PANTR             Reviewed;         123 AA.
AC   A4K2N9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=WAP four-disulfide core domain protein 5;
DE   Flags: Precursor;
GN   Name=WFDC5;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17267810; DOI=10.1101/gr.6004607;
RG   NISC comparative sequencing program;
RA   Hurle B., Swanson W., Green E.D.;
RT   "Comparative sequence analyses reveal rapid and divergent evolutionary
RT   changes of the WFDC locus in the primate lineage.";
RL   Genome Res. 17:276-286(2007).
CC   -!- FUNCTION: Putative acid-stable proteinase inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; DP000037; ABO52924.1; -; Genomic_DNA.
DR   RefSeq; NP_001129326.1; NM_001135854.1.
DR   AlphaFoldDB; A4K2N9; -.
DR   SMR; A4K2N9; -.
DR   STRING; 9598.ENSPTRP00000052112; -.
DR   PaxDb; A4K2N9; -.
DR   GeneID; 740370; -.
DR   KEGG; ptr:740370; -.
DR   CTD; 149708; -.
DR   eggNOG; ENOG502S99V; Eukaryota.
DR   HOGENOM; CLU_105901_2_0_1; -.
DR   InParanoid; A4K2N9; -.
DR   OrthoDB; 1560605at2759; -.
DR   TreeFam; TF338375; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   Gene3D; 4.10.75.10; -; 2.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   Pfam; PF00095; WAP; 2.
DR   PRINTS; PR00003; 4DISULPHCORE.
DR   SMART; SM00217; WAP; 2.
DR   SUPFAM; SSF57256; SSF57256; 2.
DR   PROSITE; PS51390; WAP; 2.
PE   3: Inferred from homology;
KW   Disulfide bond; Protease inhibitor; Reference proteome; Repeat; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..123
FT                   /note="WAP four-disulfide core domain protein 5"
FT                   /id="PRO_0000289641"
FT   DOMAIN          27..73
FT                   /note="WAP 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DOMAIN          74..121
FT                   /note="WAP 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        34..62
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        41..66
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        49..61
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        55..70
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        81..109
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        88..113
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        96..108
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT   DISULFID        102..117
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
SQ   SEQUENCE   123 AA;  13313 MW;  255B5501B24F54F4 CRC64;
     MRTQSLLLLG ALLAVGSQLP AVFGRKKGEK SGGCPPDDGP CLLSVPDQCV EDSQCPLTRK
     CCYRACFRQC VPRVSVKLGS CPEDQLRCLS PMNHLCHKDS DCSGKKRCCH SACGRDCRDP
     ARG