WFDC6_HUMAN
ID WFDC6_HUMAN Reviewed; 131 AA.
AC Q9BQY6; Q3MJ23; Q5JYQ4; Q8NFV6;
DT 16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=WAP four-disulfide core domain protein 6;
DE AltName: Full=Putative protease inhibitor WAP6;
DE Flags: Precursor;
GN Name=WFDC6; Synonyms=C20orf171, WAP6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=12206714; DOI=10.1042/bj20020869;
RA Clauss A., Lilja H., Lundwall A.;
RT "A locus on human chromosome 20 contains several genes expressing protease
RT inhibitor domains with homology to whey acidic protein.";
RL Biochem. J. 368:233-242(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1).
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BQY6-2; Q15323: KRT31; NbExp=3; IntAct=EBI-12176563, EBI-948001;
CC Q9BQY6-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12176563, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9BQY6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BQY6-2; Sequence=VSP_007550, VSP_007551;
CC Name=3;
CC IsoId=O95925-3; Sequence=External;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed, but the highest levels are
CC found in epididymis, testis and trachea.
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DR EMBL; AF411861; AAN03684.1; -; mRNA.
DR EMBL; AL031663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101600; AAI01601.1; -; mRNA.
DR EMBL; BC101604; AAI01605.1; -; mRNA.
DR CCDS; CCDS13358.1; -. [Q9BQY6-2]
DR RefSeq; NP_543017.1; NM_080827.1. [Q9BQY6-2]
DR AlphaFoldDB; Q9BQY6; -.
DR SMR; Q9BQY6; -.
DR BioGRID; 126742; 11.
DR IntAct; Q9BQY6; 2.
DR STRING; 9606.ENSP00000361755; -.
DR MEROPS; I17.953; -.
DR BioMuta; WFDC6; -.
DR DMDM; 32130307; -.
DR MassIVE; Q9BQY6; -.
DR PeptideAtlas; Q9BQY6; -.
DR PRIDE; Q9BQY6; -.
DR Antibodypedia; 76903; 3 antibodies from 3 providers.
DR DNASU; 140870; -.
DR Ensembl; ENST00000372665.3; ENSP00000361750.3; ENSG00000243543.9. [Q9BQY6-1]
DR Ensembl; ENST00000372670.8; ENSP00000361755.3; ENSG00000243543.9. [Q9BQY6-2]
DR GeneID; 140870; -.
DR KEGG; hsa:140870; -.
DR MANE-Select; ENST00000372670.8; ENSP00000361755.3; NM_080827.2; NP_543017.1. [Q9BQY6-2]
DR UCSC; uc002xos.2; human. [Q9BQY6-1]
DR CTD; 140870; -.
DR GeneCards; EPPIN-WFDC6; -.
DR GeneCards; WFDC6; -.
DR HGNC; HGNC:38825; EPPIN-WFDC6.
DR HGNC; HGNC:16164; WFDC6.
DR HPA; ENSG00000243543; Tissue enriched (epididymis).
DR neXtProt; NX_Q9BQY6; -.
DR OpenTargets; ENSG00000243543; -.
DR PharmGKB; PA25714; -.
DR VEuPathDB; HostDB:ENSG00000243543; -.
DR eggNOG; KOG4295; Eukaryota.
DR GeneTree; ENSGT00940000164575; -.
DR HOGENOM; CLU_2468453_0_0_1; -.
DR OMA; CMYSCGK; -.
DR PhylomeDB; Q9BQY6; -.
DR PathwayCommons; Q9BQY6; -.
DR SignaLink; Q9BQY6; -.
DR BioGRID-ORCS; 140870; 12 hits in 1063 CRISPR screens.
DR ChiTaRS; WFDC6; human.
DR GenomeRNAi; 140870; -.
DR Pharos; Q9BQY6; Tdark.
DR PRO; PR:Q9BQY6; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BQY6; protein.
DR Bgee; ENSG00000243543; Expressed in left testis and 66 other tissues.
DR ExpressionAtlas; Q9BQY6; baseline and differential.
DR Genevisible; Q9BQY6; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 4.10.410.10; -; 1.
DR Gene3D; 4.10.75.10; -; 1.
DR InterPro; IPR036645; Elafin-like_sf.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR008197; WAP_dom.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00095; WAP; 1.
DR SMART; SM00131; KU; 1.
DR SUPFAM; SSF57256; SSF57256; 1.
DR SUPFAM; SSF57362; SSF57362; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS51390; WAP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Protease inhibitor;
KW Reference proteome; Secreted; Serine protease inhibitor; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..131
FT /note="WAP four-disulfide core domain protein 6"
FT /id="PRO_0000041383"
FT DOMAIN 26..73
FT /note="WAP; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722"
FT DOMAIN 70..128
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 33..61
FT /evidence="ECO:0000250"
FT DISULFID 48..60
FT /evidence="ECO:0000250"
FT DISULFID 54..69
FT /evidence="ECO:0000250"
FT DISULFID 79..127
FT /evidence="ECO:0000250"
FT DISULFID 102..123
FT /evidence="ECO:0000250"
FT VAR_SEQ 75..86
FT /note="IYAVCHRRLAPA -> VSLTLYHKEELE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12206714,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_007550"
FT VAR_SEQ 87..131
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12206714,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_007551"
SQ SEQUENCE 131 AA; 14626 MW; 2F6D06EF43EB7564 CRC64;
MGLSGLLPIL VPFILLGDIQ EPGHAEGILG KPCPKIKVEC EVEEIDQCTK PRDCPENMKC
CPFSRGKKCL DFRKIYAVCH RRLAPAWPPY HTGGTIKKTK ICSEFIYGGS QGNNNNFQTE
AICLVTCKKY H
