WFDC9_HUMAN
ID WFDC9_HUMAN Reviewed; 89 AA.
AC Q8NEX5; Q3MIX6; Q5TGZ8;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein WFDC9;
DE Flags: Precursor;
GN Name=WFDC9; Synonyms=WAP9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12206714; DOI=10.1042/bj20020869;
RA Clauss A., Lilja H., Lundwall A.;
RT "A locus on human chromosome 20 contains several genes expressing protease
RT inhibitor domains with homology to whey acidic protein.";
RL Biochem. J. 368:233-242(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NEX5; P50222: MEOX2; NbExp=3; IntAct=EBI-10270812, EBI-748397;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- MISCELLANEOUS: Although this protein was isolated in a region
CC containing several WAP proteins and was defined as a WAP protein, it
CC does not contain a classical WAP domain.
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DR EMBL; AY047610; AAK97772.1; -; mRNA.
DR EMBL; AL031671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069295; AAH69295.1; -; mRNA.
DR EMBL; BC101652; AAI01653.1; -; mRNA.
DR EMBL; BC101656; AAI01657.1; -; mRNA.
DR CCDS; CCDS13362.1; -.
DR RefSeq; NP_671731.1; NM_147198.3.
DR AlphaFoldDB; Q8NEX5; -.
DR BioGRID; 129232; 11.
DR IntAct; Q8NEX5; 4.
DR STRING; 9606.ENSP00000320532; -.
DR iPTMnet; Q8NEX5; -.
DR PhosphoSitePlus; Q8NEX5; -.
DR BioMuta; WFDC9; -.
DR DMDM; 26401304; -.
DR MassIVE; Q8NEX5; -.
DR PaxDb; Q8NEX5; -.
DR PeptideAtlas; Q8NEX5; -.
DR PRIDE; Q8NEX5; -.
DR ProteomicsDB; 73227; -.
DR Antibodypedia; 53788; 30 antibodies from 5 providers.
DR DNASU; 259240; -.
DR Ensembl; ENST00000326000.2; ENSP00000320532.1; ENSG00000180205.4.
DR GeneID; 259240; -.
DR KEGG; hsa:259240; -.
DR MANE-Select; ENST00000326000.2; ENSP00000320532.1; NM_147198.4; NP_671731.1.
DR UCSC; uc002xoy.3; human.
DR CTD; 259240; -.
DR GeneCards; WFDC9; -.
DR HGNC; HGNC:20380; WFDC9.
DR HPA; ENSG00000180205; Tissue enriched (epididymis).
DR neXtProt; NX_Q8NEX5; -.
DR PharmGKB; PA134934414; -.
DR VEuPathDB; HostDB:ENSG00000180205; -.
DR eggNOG; ENOG502TGNJ; Eukaryota.
DR GeneTree; ENSGT00940000162961; -.
DR HOGENOM; CLU_191873_0_0_1; -.
DR InParanoid; Q8NEX5; -.
DR OMA; IEQCWVQ; -.
DR OrthoDB; 1527219at2759; -.
DR PhylomeDB; Q8NEX5; -.
DR TreeFam; TF338513; -.
DR PathwayCommons; Q8NEX5; -.
DR SignaLink; Q8NEX5; -.
DR BioGRID-ORCS; 259240; 43 hits in 1018 CRISPR screens.
DR ChiTaRS; WFDC9; human.
DR GenomeRNAi; 259240; -.
DR Pharos; Q8NEX5; Tdark.
DR PRO; PR:Q8NEX5; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8NEX5; protein.
DR Bgee; ENSG00000180205; Expressed in corpus epididymis and 17 other tissues.
DR Genevisible; Q8NEX5; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR InterPro; IPR029725; WFDC9.
DR PANTHER; PTHR19441:SF16; PTHR19441:SF16; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..89
FT /note="Protein WFDC9"
FT /id="PRO_0000041385"
FT VARIANT 27
FT /note="N -> T (in dbSNP:rs2245898)"
FT /id="VAR_021911"
SQ SEQUENCE 89 AA; 10506 MW; 9CC9B2013FA679EB CRC64;
MKPWILLLVM FISGVVMLLP VLGSFWNKDP FLDMIRETEQ CWVQPPYKYC EKRCTKIMTC
VRPNHTCCWT YCGNICLDNE EPLKSMLNP
