WGE_DROME
ID WGE_DROME Reviewed; 1658 AA.
AC Q3LHL9; C6TPA0; Q7KS56; Q8MSX3; Q9VCV6;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein winged eye;
GN Name=wge; ORFNames=CG31151;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND DOMAIN.
RX PubMed=16247005; DOI=10.1073/pnas.0507945102;
RA Katsuyama T., Sugawara T., Tatsumi M., Oshima Y., Gehring W.J., Aigaki T.,
RA Kurata S.;
RT "Involvement of winged eye encoding a chromatin-associated bromo-adjacent
RT homology domain protein in disc specification.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:15918-15923(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Berkeley {ECO:0000312|EMBL:ACU43548.1};
RC TISSUE=Larva {ECO:0000312|EMBL:ACU43548.1}, and
RC Pupae {ECO:0000312|EMBL:ACU43548.1};
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 296-1658.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-546, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Functions in the determination of disk-specific identity,
CC downstream of Hox genes. Overexpression induces ectopic wings with
CC antero-posterior and dorso-ventral axes in the eye field.
CC Overexpression is sufficient for ectopic expression of vg in eye disks.
CC {ECO:0000269|PubMed:16247005}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16247005}. Chromosome
CC {ECO:0000269|PubMed:16247005}. Note=Chromatin-associated; colocalizes
CC on polytene chromosomes with Psc.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000305}; Synonyms=C {ECO:0000312|FlyBase:FBgn0051151};
CC IsoId=Q3LHL9-1; Sequence=Displayed;
CC Name=2 {ECO:0000305}; Synonyms=D {ECO:0000312|FlyBase:FBgn0051151};
CC IsoId=Q3LHL9-3; Sequence=VSP_058153;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed throughout the larval and
CC pupal developmental stages in larval tissues and imaginal disks.
CC {ECO:0000269|PubMed:16247005}.
CC -!- DOMAIN: The BAH domain is required for localization to specific sites
CC on polytene chromosomes. {ECO:0000269|PubMed:16247005}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF56049.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM49885.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB190214; BAE45705.1; -; mRNA.
DR EMBL; AE014297; AAF56049.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AE014297; AAF56050.4; -; Genomic_DNA.
DR EMBL; AE014297; ABI31197.1; -; Genomic_DNA.
DR EMBL; BT099586; ACU43548.1; -; mRNA.
DR EMBL; AY118516; AAM49885.1; ALT_INIT; mRNA.
DR RefSeq; NP_001036746.1; NM_001043281.2. [Q3LHL9-1]
DR RefSeq; NP_732790.3; NM_170037.2. [Q3LHL9-3]
DR RefSeq; NP_732791.2; NM_170038.2.
DR AlphaFoldDB; Q3LHL9; -.
DR SMR; Q3LHL9; -.
DR BioGRID; 67637; 5.
DR IntAct; Q3LHL9; 4.
DR STRING; 7227.FBpp0302573; -.
DR iPTMnet; Q3LHL9; -.
DR PaxDb; Q3LHL9; -.
DR DNASU; 42687; -.
DR EnsemblMetazoa; FBtr0110835; FBpp0110132; FBgn0051151. [Q3LHL9-1]
DR EnsemblMetazoa; FBtr0310425; FBpp0302573; FBgn0051151. [Q3LHL9-3]
DR GeneID; 42687; -.
DR KEGG; dme:Dmel_CG31151; -.
DR UCSC; CG31151-RA; d. melanogaster.
DR UCSC; CG31151-RB; d. melanogaster.
DR UCSC; CG31151-RC; d. melanogaster. [Q3LHL9-1]
DR CTD; 42687; -.
DR FlyBase; FBgn0051151; wge.
DR VEuPathDB; VectorBase:FBgn0051151; -.
DR eggNOG; KOG1886; Eukaryota.
DR GeneTree; ENSGT00940000173476; -.
DR InParanoid; Q3LHL9; -.
DR PhylomeDB; Q3LHL9; -.
DR SignaLink; Q3LHL9; -.
DR BioGRID-ORCS; 42687; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 42687; -.
DR PRO; PR:Q3LHL9; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0051151; Expressed in spermathecum and 25 other tissues.
DR ExpressionAtlas; Q3LHL9; baseline and differential.
DR Genevisible; Q3LHL9; DM.
DR GO; GO:0000785; C:chromatin; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007560; P:imaginal disc morphogenesis; IMP:UniProtKB.
DR Gene3D; 2.30.30.490; -; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR029616; Wge.
DR PANTHER; PTHR12505:SF24; PTHR12505:SF24; 3.
DR Pfam; PF01426; BAH; 1.
DR SMART; SM00439; BAH; 1.
DR PROSITE; PS51038; BAH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosome; Developmental protein; Differentiation;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..1658
FT /note="Protein winged eye"
FT /id="PRO_0000355632"
FT DOMAIN 1510..1634
FT /note="BAH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00370"
FT REGION 85..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..866
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..947
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..976
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1011..1032
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1385
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1392..1425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 546
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 281
FT /note="L -> LGISNFPLLTPT (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_058153"
SQ SEQUENCE 1658 AA; 178316 MW; B003A099AAD45C4A CRC64;
MATFNPGASS SAADVLSATT ATATFLVPTT AAVSHPGAHT AHLQLDQFGG FSAATATPLQ
HHHHQQTNSS YTFVQIKREP CQVSEISSNN CHQQQQQHHQ HHQHQVQHQG LSSASMTASS
KTMSSSTLTT LVKIEAPSPK VSELEKSTGN SVPIGIAVAR KRPQEALVPA INTPATLPLQ
PPLNKDLNCF GIRVADLGAT SCGNLYFTGN GDLMTTGTAT AEELALSAAG VNRAPSTFWQ
YPNALPIESV ISMSPATVGL QYSREASRGQ VVLLPAGPTA LDPFQQAAAA AAFVWPSAYI
PQAPAPGGHS AAAAAAAASL QPTPNLSSLP NFIFPSMGGH QALSTTPSYA STLQLYLAAA
ATATGSSTMC QHSNQQTSTT TTNSTINLSL AAGSGVTQSG NAASSLSSSS SLSASSSRFL
SLATGQTGIP SLLSLPPPTG LKEEYPMPLA LPPLVPLEAA RDKEQALNLM RLPTPPTSAT
MEPSSLGHAT PHHLFQSGAM ATPTPALLNL SMHGNGGELP AATPLPAVSD EAALNYKLHA
PLTPQTPPRL ADIPVSGSTQ LLPQMQDVNI QTDTPVCSED ESFPGSAKPQ DPAAEAFPPP
THVQPLELTK PSEASHTQPT ECHTQTEPSD IPSASQEESA EQTPPEPIET MTQATQADQT
SPEDLTGLEL LSNISTNSKP LVRVKQEPVE HIEQPAPQPQ PVNIMPSEPT LPMPPMLEME
PTSEREPLGG LKLLCALAEQ RIQEEVVQGS SLFATPSSRT PTPTSLALGT TAATPPIFEA
KSCYAFGQSQ GSVFPSSTSS FQMPLSSPGF PSMQGIELPT TSAGIVAELT PVKRKKHKHS
KSSGSDSRKS ARCSKKSKKK RHHSSSRQQF SAPAEEDLDL QDDQLQSELR NALHAVDPSY
AQRFGQEVFS IMDNSMRMRL AKITRQYRKK KRKLDEISKH KKKKKCSKQQ LELQQQQASQ
QAVQPSSALQ QPQMTLSSVL GTSSPLRDYK FPKFSSSNLQ ASSFLRFPDK THSFPPPPSL
QQSQPEPNPL PSSSSPSTSS FVRLEPSALD AAVAIAPTTS STSTSGSPST KQVASARKQR
KMKASTVGAA GEQTAATEAK RRFSAIDREL QLTSEHLYRD ETRVLTDMGG LFYAGVMKPL
RPPDVYSITL DGERGNKSHV MSREDILKDT ILEVAPKSVE SVPVGTRLCA YWSQQYRCLY
PGRAIDSEQV VDGTASSATN AATTAPDFVS VEFDDGDSGR IRLQNIRMLL SDYPIAEYND
NPLYSVGKQK RSALRGGESG PGGVTQDHLT VPGCEDSHSH HSLGMSSDNT TSLAATMELF
TQRSEKKRLK KSLKKMSKAQ NGVSPATATN GGADAAALGD GVSAEDAARK HHKHKKRKKH
KKHHRKNGSE EQEQQVVQQD YSAAGQEATE APSTEMSSAT SSRVKVEVKV KTEQLEMEEE
ESASNLMSEI SDEAKGDDLV EHNNSKGSSK IAAFLPERQL WGWYGTAYRK AGVKGRARKQ
FYKTIKRGKE TITVGDSAVF LSTGRPDRPY IGRIESMWET TTGNKVVRVA WFYHPEETTG
CPKLKFPGAL FESPHEDEND VQTISHRCEV LQFGSYFEKF GADSKQYQSI YDNNDTYYLA
GHYNPRLQVL KLQDDIPTLE ELQDTNTTTT TTETTTED
