WHIA_BIFLS
ID WHIA_BIFLS Reviewed; 316 AA.
AC B7GQU6; E8MJH1;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN OrderedLocusNames=Blon_1086, BLIJ_1110;
OS Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM
OS 1222 / NCTC 11817 / S12).
OC Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC Bifidobacterium.
OX NCBI_TaxID=391904;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12;
RX PubMed=19033196; DOI=10.1073/pnas.0809584105;
RA Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R.,
RA Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P.,
RA Richardson P.M., Mills D.A.;
RT "The genome sequence of Bifidobacterium longum subsp. infantis reveals
RT adaptations for milk utilization within the infant microbiome.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12;
RX PubMed=21270894; DOI=10.1038/nature09646;
RA Fukuda S., Toh H., Hase K., Oshima K., Nakanishi Y., Yoshimura K., Tobe T.,
RA Clarke J.M., Topping D.L., Suzuki T., Taylor T.D., Itoh K., Kikuchi J.,
RA Morita H., Hattori M., Ohno H.;
RT "Bifidobacteria can protect from enteropathogenic infection through
RT production of acetate.";
RL Nature 469:543-547(2011).
CC -!- FUNCTION: Involved in cell division and chromosome segregation.
CC {ECO:0000255|HAMAP-Rule:MF_01420}.
CC -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC Rule:MF_01420}.
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DR EMBL; CP001095; ACJ52176.1; -; Genomic_DNA.
DR EMBL; AP010889; BAJ68698.1; -; Genomic_DNA.
DR RefSeq; WP_012577435.1; NZ_JDTT01000017.1.
DR AlphaFoldDB; B7GQU6; -.
DR SMR; B7GQU6; -.
DR PRIDE; B7GQU6; -.
DR EnsemblBacteria; ACJ52176; ACJ52176; Blon_1086.
DR KEGG; bln:Blon_1086; -.
DR KEGG; blon:BLIJ_1110; -.
DR PATRIC; fig|391904.8.peg.1109; -.
DR HOGENOM; CLU_053282_0_0_11; -.
DR OMA; CDAEAAW; -.
DR Proteomes; UP000001360; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR Gene3D; 3.10.28.10; -; 1.
DR HAMAP; MF_01420; HTH_type_WhiA; 1.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR InterPro; IPR003802; Sporulation_regulator_WhiA.
DR InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR PANTHER; PTHR37307; PTHR37307; 1.
DR Pfam; PF02650; HTH_WhiA; 1.
DR Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR Pfam; PF10298; WhiA_N; 1.
DR TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; DNA-binding.
FT CHAIN 1..316
FT /note="Probable cell division protein WhiA"
FT /id="PRO_0000376450"
FT DNA_BIND 276..309
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ SEQUENCE 316 AA; 34512 MW; 9EE4E65DBA5A2D6E CRC64;
MALLDDVKSE LAAFEGDSPA AIKAQAAAMI RFGGGLRPVQ NTYVIQAVFT SLDVAEWLKN
TLRNTFGHEA EINHLTRQTP NGPVETYVVL VTRNVVALAL QTGLVDRRKQ QVRGLPSEVV
NGSIAQIKAA WRGAFMARGF LSDPGKASFL EIACPTEEAA MALCGVARRL GIQAKHRTLR
SSERVTLKDP DAIERMLKLM GATRSAREWT GKRSDGEARG KANRLANFDD ANMRRSAKAA
AEASEKVQHA FEVLGDNIPD NLRQAGQLRI DHVDKSLEEL GKIAEPQITK DAIAGRIRRL
LQLAEKTEKA RAAEGK
