WHIA_CLOBH
ID WHIA_CLOBH Reviewed; 315 AA.
AC A5I7A0; A7G8I3;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN OrderedLocusNames=CBO3375, CLC_3318;
OS Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=441771;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A;
RX PubMed=17519437; DOI=10.1101/gr.6282807;
RA Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G.,
RA Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L.,
RA Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M.,
RA Churcher C., Quail M.A., Chillingworth T., Feltwell T., Fraser A.,
RA Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S.,
RA Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA White B., Whithead S., Parkhill J.;
RT "Genome sequence of a proteolytic (Group I) Clostridium botulinum strain
RT Hall A and comparative analysis of the clostridial genomes.";
RL Genome Res. 17:1082-1092(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A;
RX PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT plasmids.";
RL PLoS ONE 2:E1271-E1271(2007).
CC -!- FUNCTION: Involved in cell division and chromosome segregation.
CC {ECO:0000255|HAMAP-Rule:MF_01420}.
CC -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC Rule:MF_01420}.
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DR EMBL; CP000727; ABS37671.1; -; Genomic_DNA.
DR EMBL; AM412317; CAL84934.1; -; Genomic_DNA.
DR RefSeq; WP_003357358.1; NC_009698.1.
DR RefSeq; YP_001255857.1; NC_009495.1.
DR RefSeq; YP_001389098.1; NC_009698.1.
DR AlphaFoldDB; A5I7A0; -.
DR SMR; A5I7A0; -.
DR GeneID; 5187629; -.
DR KEGG; cbh:CLC_3318; -.
DR KEGG; cbo:CBO3375; -.
DR PATRIC; fig|413999.7.peg.3349; -.
DR HOGENOM; CLU_053282_0_0_9; -.
DR OMA; CDAEAAW; -.
DR PRO; PR:A5I7A0; -.
DR Proteomes; UP000001986; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0043937; P:regulation of sporulation; IBA:GO_Central.
DR Gene3D; 3.10.28.10; -; 1.
DR HAMAP; MF_01420; HTH_type_WhiA; 1.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR InterPro; IPR003802; Sporulation_regulator_WhiA.
DR InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR PANTHER; PTHR37307; PTHR37307; 1.
DR Pfam; PF02650; HTH_WhiA; 1.
DR Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR Pfam; PF10298; WhiA_N; 1.
DR SUPFAM; SSF55608; SSF55608; 1.
DR TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; DNA-binding; Reference proteome.
FT CHAIN 1..315
FT /note="Probable cell division protein WhiA"
FT /id="PRO_0000376460"
FT DNA_BIND 280..313
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ SEQUENCE 315 AA; 35924 MW; CB67F89F7687EA5F CRC64;
MSFSLKVKNE VCKHVEVNKQ EAIAELSAIM KVSGTLLFTN KQFNFKITTE NAAIARLVFK
ILKEHFGIHT EIMIKKNNSL KKNNIYIILI SEEEGVKSLL KEVGIIKETI NVFSLDYNIP
KSIIECDECR RAYIRGAFLG GGSISNPEKT YHLEFVTHNE EYAKDLSNLI NSYNLNSKVI
KRKNSYIIYL KEGEQIVDLL NIIGAHASLL ELENVRIMKE MRNNVNRLVN CETANLSKTV
NAAVRQVESI KFIEREIGLG RLPKNLRDVA ELRIKYPDES LRELGKMLNP PVGKSGVNHR
LRRIEKIADE LKQGI