ID   WHIA_CLOD6              Reviewed;         315 AA.
AC   Q180P5;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420}; OrderedLocusNames=CD630_33970;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- FUNCTION: Involved in cell division and chromosome segregation.
CC       {ECO:0000255|HAMAP-Rule:MF_01420}.
CC   -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01420}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAJ70300.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AM180355; CAJ70300.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_003436252.1; NZ_CP010905.2.
DR   RefSeq; YP_001089917.1; NC_009089.1.
DR   AlphaFoldDB; Q180P5; -.
DR   SMR; Q180P5; -.
DR   STRING; 272563.CD630_33970; -.
DR   EnsemblBacteria; CAJ70300; CAJ70300; CD630_33970.
DR   GeneID; 66355854; -.
DR   KEGG; cdf:CD630_33970; -.
DR   KEGG; pdc:CDIF630_03702; -.
DR   PATRIC; fig|272563.120.peg.3591; -.
DR   eggNOG; COG1481; Bacteria.
DR   PhylomeDB; Q180P5; -.
DR   BioCyc; PDIF272563:G12WB-3571-MON; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR   Gene3D; 3.10.28.10; -; 1.
DR   HAMAP; MF_01420; HTH_type_WhiA; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR   InterPro; IPR003802; Sporulation_regulator_WhiA.
DR   InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR   InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR   PANTHER; PTHR37307; PTHR37307; 1.
DR   Pfam; PF02650; HTH_WhiA; 1.
DR   Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR   Pfam; PF10298; WhiA_N; 1.
DR   SUPFAM; SSF55608; SSF55608; 1.
DR   TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA-binding; Reference proteome.
FT   CHAIN           1..315
FT                   /note="Probable cell division protein WhiA"
FT                   /id="PRO_0000376464"
FT   DNA_BIND        280..313
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ   SEQUENCE   315 AA;  35341 MW;  F13097F1D8F1D226 CRC64;
     MSFSTETKNE LARVISGNEC CNIAELSALV KSGGSIQIVG YKKLNLKITT ELNSIARKVF
     KLLKKNFNIN TTISVNKNQM LKRNNSYVLM VTSEMGSEML LKKLGILEDK EGFFTINKIS
     ENLIKHEGCK RAFIRGAFLG GGSISDPEKN YHMEFVTNNE EFADSLKELI NSLGFNSKIV
     ARKNNHVVYI KESEQISDLL SIIGGHHALL SLQNTKIVKE MRNNVNRIVN CETANLSKTV
     NAAVRQVENI KLIQETIGIS SLPENLQEIA KIRIEYEDMT LKELGEMLEP PIGKSGVNHR
     LRKIEEIATD LKKKS