ID   WHIA_LACAC              Reviewed;         311 AA.
AC   Q5FL56;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420}; OrderedLocusNames=LBA0693;
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   -!- FUNCTION: Involved in cell division and chromosome segregation.
CC       {ECO:0000255|HAMAP-Rule:MF_01420}.
CC   -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01420}.
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DR   EMBL; CP000033; AAV42568.1; -; Genomic_DNA.
DR   RefSeq; WP_003546596.1; NC_006814.3.
DR   RefSeq; YP_193599.1; NC_006814.3.
DR   AlphaFoldDB; Q5FL56; -.
DR   SMR; Q5FL56; -.
DR   STRING; 272621.LBA0693; -.
DR   PRIDE; Q5FL56; -.
DR   EnsemblBacteria; AAV42568; AAV42568; LBA0693.
DR   GeneID; 56942324; -.
DR   KEGG; lac:LBA0693; -.
DR   PATRIC; fig|272621.13.peg.662; -.
DR   eggNOG; COG1481; Bacteria.
DR   HOGENOM; CLU_053282_1_0_9; -.
DR   OMA; CDAEAAW; -.
DR   BioCyc; LACI272621:G1G49-714-MON; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR   Gene3D; 3.10.28.10; -; 1.
DR   HAMAP; MF_01420; HTH_type_WhiA; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR   InterPro; IPR003802; Sporulation_regulator_WhiA.
DR   InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR   InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR   PANTHER; PTHR37307; PTHR37307; 1.
DR   Pfam; PF02650; HTH_WhiA; 1.
DR   Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR   Pfam; PF10298; WhiA_N; 1.
DR   SUPFAM; SSF55608; SSF55608; 1.
DR   TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA-binding; Reference proteome.
FT   CHAIN           1..311
FT                   /note="Probable cell division protein WhiA"
FT                   /id="PRO_0000376493"
FT   DNA_BIND        277..311
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ   SEQUENCE   311 AA;  35724 MW;  27BCDE814D0BC2F9 CRC64;
     MASYASEVKK ELTSLEVHPE HAKAELAAFL RMNGVLNLHD HQFSLDITTE NPAIARRIFK
     LIKVAYGIEP LLIVSRKMKL KKNNQYLVRL NQQVQEILEN LQIWDTEKGL VTRIPKRIMS
     SREGAMSYLR GAFLAGGSVN NPETSRYHLE IYSTYEDHNE DLAKLMNEYF YLNAKMTKRR
     RGYIVYLKEA EKIGDFLHIV GALNAMLNFE DLRIMRDMRN SVNRLVNCDT ANMKKTASAS
     AKQVEDIQLI QKEKGLDDLS EKLQILANFR LAHPELTLKE VADQIPDGPI SKSGVNHRFK
     KLHEIAESLR E