ID   WHIA_LACLA              Reviewed;         305 AA.
AC   Q9CGX9;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420}; OrderedLocusNames=LL0963;
GN   ORFNames=L190464;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Involved in cell division and chromosome segregation.
CC       {ECO:0000255|HAMAP-Rule:MF_01420}.
CC   -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01420}.
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DR   EMBL; AE005176; AAK05061.1; -; Genomic_DNA.
DR   PIR; C86745; C86745.
DR   RefSeq; NP_267119.1; NC_002662.1.
DR   RefSeq; WP_003130947.1; NC_002662.1.
DR   AlphaFoldDB; Q9CGX9; -.
DR   SMR; Q9CGX9; -.
DR   STRING; 272623.L190464; -.
DR   PaxDb; Q9CGX9; -.
DR   EnsemblBacteria; AAK05061; AAK05061; L190464.
DR   KEGG; lla:L190464; -.
DR   PATRIC; fig|272623.7.peg.1030; -.
DR   eggNOG; COG1481; Bacteria.
DR   HOGENOM; CLU_053282_0_0_9; -.
DR   OMA; CDAEAAW; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR   Gene3D; 3.10.28.10; -; 1.
DR   HAMAP; MF_01420; HTH_type_WhiA; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR   InterPro; IPR003802; Sporulation_regulator_WhiA.
DR   InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR   InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR   PANTHER; PTHR37307; PTHR37307; 1.
DR   Pfam; PF02650; HTH_WhiA; 1.
DR   Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR   Pfam; PF10298; WhiA_N; 1.
DR   SUPFAM; SSF55608; SSF55608; 1.
DR   TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA-binding; Reference proteome.
FT   CHAIN           1..305
FT                   /note="Probable cell division protein WhiA"
FT                   /id="PRO_0000376510"
FT   DNA_BIND        269..302
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ   SEQUENCE   305 AA;  34613 MW;  2B44F09EBD67BE21 CRC64;
     MSFTSDVKKE LTSNLATTGA LLALVRMNGS VGIFNGLTLS ITTENAGTAK YIYQMLRELY
     DVHAEIRVHQ KTTLSKNRVY TVFITEGASE LLDELSLADS LMLDNGVPEF VKNDEFIKKD
     YLRGAFLSAG SLHNPEKGEY QLSIASVYQE HAEDLQEIFR DFGLNARVIE RKNRWILYLS
     KAEEIMDFLT LIGAMKARLK FEEAKIMREM RGLANRQSNF ENANIAKSVM AAQEAINAIK
     FLNERKELEQ LPENLKEIAR VRLENPEATI KELGELLEPS LGKSGVNHRL RKLVEQANEL
     RKIEN