ID   WHIA_LACLM              Reviewed;         305 AA.
AC   A2RLG3;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420}; OrderedLocusNames=llmg_1555;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- FUNCTION: Involved in cell division and chromosome segregation.
CC       {ECO:0000255|HAMAP-Rule:MF_01420}.
CC   -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01420}.
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DR   EMBL; AM406671; CAL98130.1; -; Genomic_DNA.
DR   RefSeq; WP_011675974.1; NZ_WJVF01000002.1.
DR   AlphaFoldDB; A2RLG3; -.
DR   SMR; A2RLG3; -.
DR   STRING; 416870.llmg_1555; -.
DR   EnsemblBacteria; CAL98130; CAL98130; llmg_1555.
DR   GeneID; 61109269; -.
DR   KEGG; llm:llmg_1555; -.
DR   eggNOG; COG1481; Bacteria.
DR   HOGENOM; CLU_053282_0_0_9; -.
DR   OMA; CDAEAAW; -.
DR   PhylomeDB; A2RLG3; -.
DR   BioCyc; LLAC416870:LLMG_RS07815-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR   Gene3D; 3.10.28.10; -; 1.
DR   HAMAP; MF_01420; HTH_type_WhiA; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR   InterPro; IPR003802; Sporulation_regulator_WhiA.
DR   InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR   InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR   PANTHER; PTHR37307; PTHR37307; 1.
DR   Pfam; PF02650; HTH_WhiA; 1.
DR   Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR   Pfam; PF10298; WhiA_N; 1.
DR   SUPFAM; SSF55608; SSF55608; 1.
DR   TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA-binding.
FT   CHAIN           1..305
FT                   /note="Probable cell division protein WhiA"
FT                   /id="PRO_0000376508"
FT   DNA_BIND        269..302
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ   SEQUENCE   305 AA;  34548 MW;  01523E714A10DD0D CRC64;
     MSFTSDVKKE LTRNLATTGA LLALVRMNGS VGIFNGLTLS ITTENAGTAK YIYQMLQELY
     EIHAEIRVHQ KTTLSKNRVY TVFITEGAGE LLDELSLADS LMLDNGVPEF VKNDEFIKKD
     YLRGAFLSAG ALHNPEKGEY QLSIANVYQE HAEDLQEIFR DFGLNARVIE RKNRWILYLS
     KAEEIMDFLT LIGAMKARLK FEEAKIMREM RGLANRQSNF ENANIAKSVM AAQEAIDAIQ
     FLNEKKELEQ LPPSLKEIAR LRLENPEATI KELGELLDPP LGKSGVNHRL RKLVERSNDL
     KKVES