WHIA_MYCBO
ID WHIA_MYCBO Reviewed; 327 AA.
AC Q7U040; A0A1R3XYA6; X2BHW9;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-MAY-2022, sequence version 2.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN OrderedLocusNames=BQ2027_MB1458;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: Involved in cell division and chromosome segregation.
CC {ECO:0000255|HAMAP-Rule:MF_01420}.
CC -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC Rule:MF_01420}.
CC -!- SEQUENCE CAUTION:
CC Sequence=SIU00061.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000250|UniProtKB:P9WF45};
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DR EMBL; LT708304; SIU00061.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_855110.1; NC_002945.3.
DR RefSeq; WP_003901156.1; NC_002945.4.
DR AlphaFoldDB; Q7U040; -.
DR SMR; Q7U040; -.
DR EnsemblBacteria; SIU00061; SIU00061; BQ2027_MB1458.
DR GeneID; 45425401; -.
DR PATRIC; fig|233413.5.peg.1593; -.
DR OMA; CDAEAAW; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR Gene3D; 3.10.28.10; -; 1.
DR HAMAP; MF_01420; HTH_type_WhiA; 1.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR InterPro; IPR003802; Sporulation_regulator_WhiA.
DR InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR PANTHER; PTHR37307; PTHR37307; 1.
DR Pfam; PF02650; HTH_WhiA; 1.
DR Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR Pfam; PF10298; WhiA_N; 1.
DR TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; DNA-binding.
FT CHAIN 1..327
FT /note="Probable cell division protein WhiA"
FT /id="PRO_0000376523"
FT DNA_BIND 275..308
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ SEQUENCE 327 AA; 35135 MW; DA43F3E276081D36 CRC64;
MAMTTDVKDE LSRLVVKSVS ARRAEVTSLL RFAGGLHIVG GRVVVEAELD LGSIARRLRK
EIFELYGYTA VVHVLSASGI RKSTRYVLRV ANDGEALARQ TGLLDMRGRP VRGLPAQVVG
GSIDDAEAAW RGAFLAHGSL TEPGRSSALE VSCPGPEAAL ALVGAARRLG VGAKAREVRG
ADRVVVRDGE AIGALLTRMG AQDTRLVWEE RRLRREVRAT ANRLANFDDA NLRRSARAAV
AAAARVERAL EILGDTVPEH LASAGKLRVE HRQASLEELG RLADPPMTKD AVAGRIRRLL
SMADRKAKVD GIPDTESVVT PDLLEDA
