ID   WHIA_MYCS2              Reviewed;         327 AA.
AC   A0QWV9; I7G187;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 3.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   OrderedLocusNames=MSMEG_3081, MSMEI_3003;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
CC   -!- FUNCTION: Involved in cell division and chromosome segregation.
CC       {ECO:0000255|HAMAP-Rule:MF_01420}.
CC   -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01420}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABK71877.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000250|UniProtKB:P9WF45};
CC       Sequence=AFP39467.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000250|UniProtKB:P9WF45};
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DR   EMBL; CP000480; ABK71877.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP001663; AFP39467.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_887397.1; NC_008596.1.
DR   AlphaFoldDB; A0QWV9; -.
DR   SMR; A0QWV9; -.
DR   STRING; 246196.MSMEI_3003; -.
DR   PRIDE; A0QWV9; -.
DR   EnsemblBacteria; ABK71877; ABK71877; MSMEG_3081.
DR   EnsemblBacteria; AFP39467; AFP39467; MSMEI_3003.
DR   KEGG; msg:MSMEI_3003; -.
DR   KEGG; msm:MSMEG_3081; -.
DR   PATRIC; fig|246196.19.peg.3042; -.
DR   eggNOG; COG1481; Bacteria.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR   Gene3D; 3.10.28.10; -; 1.
DR   HAMAP; MF_01420; HTH_type_WhiA; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR   InterPro; IPR003802; Sporulation_regulator_WhiA.
DR   InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR   InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR   PANTHER; PTHR37307; PTHR37307; 1.
DR   Pfam; PF02650; HTH_WhiA; 1.
DR   Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR   Pfam; PF10298; WhiA_N; 1.
DR   TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; DNA-binding; Reference proteome.
FT   CHAIN           1..327
FT                   /note="Probable cell division protein WhiA"
FT                   /id="PRO_0000376530"
FT   DNA_BIND        275..308
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
FT   REGION          304..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  35066 MW;  F8A9A219B20DD8A3 CRC64;
     MAMTAEVKDE LSRLVVNSVS ARRAEVASLL RFAGGLHIVA GRVVVEAEVD LGIIARRLRK
     DIYDLYGYNA VVHVLSASGI RKNTRYVVRV ANDGEALARQ TGLLDMRGRP VRGLPAQVVG
     GSVGDAEAAW RGAFLAHGSL TEPGRSSALE VSCPGPEAAL ALVGAARRLG VSAKAREVRG
     SDRVVVRDGE AIGALLTRMG AQDTRLTWEE RRMRREVRAT ANRLANFDDA NLRRSARAAV
     AAAARVERAL EILGDSVPDH LAAAGKLRVE HRQASLEELG RLADPPMTKD AVAGRIRRLL
     SMADRKAKQE GIPDTESAVT PDLLDDA