ID   WHIA_STAAC              Reviewed;         314 AA.
AC   Q5HHQ1; Q9KX04;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420}; OrderedLocusNames=SACOL0832;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10566865; DOI=10.1089/mdr.1999.5.163;
RA   de Lencastre H., Wu S.-W., Pinho M.G., Ludovice A.M., Filipe S.,
RA   Gardete S., Sobral R., Gill S.R., Chung M., Tomasz A.;
RT   "Antibiotic resistance as a stress response: complete sequencing of a large
RT   number of chromosomal loci in Staphylococcus aureus strain COL that impact
RT   on the expression of resistance to methicillin.";
RL   Microb. Drug Resist. 5:163-175(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Involved in cell division and chromosome segregation.
CC       {ECO:0000255|HAMAP-Rule:MF_01420}.
CC   -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01420}.
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DR   EMBL; Y14324; CAB82471.1; -; Genomic_DNA.
DR   EMBL; CP000046; AAW36388.1; -; Genomic_DNA.
DR   RefSeq; WP_000006551.1; NC_002951.2.
DR   AlphaFoldDB; Q5HHQ1; -.
DR   SMR; Q5HHQ1; -.
DR   EnsemblBacteria; AAW36388; AAW36388; SACOL0832.
DR   KEGG; sac:SACOL0832; -.
DR   HOGENOM; CLU_053282_0_0_9; -.
DR   OMA; CDAEAAW; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR   Gene3D; 3.10.28.10; -; 1.
DR   HAMAP; MF_01420; HTH_type_WhiA; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR   InterPro; IPR003802; Sporulation_regulator_WhiA.
DR   InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR   InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR   PANTHER; PTHR37307; PTHR37307; 1.
DR   Pfam; PF02650; HTH_WhiA; 1.
DR   Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR   Pfam; PF10298; WhiA_N; 1.
DR   SUPFAM; SSF55608; SSF55608; 1.
DR   TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA-binding.
FT   CHAIN           1..314
FT                   /note="Probable cell division protein WhiA"
FT                   /id="PRO_0000376552"
FT   DNA_BIND        274..308
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ   SEQUENCE   314 AA;  35868 MW;  5220A1A82EBB6074 CRC64;
     MSFASEMKNE LTRIDVDEMN AKAELSALIR MNGALSLSNQ QFVINVQTEN ATTARRIYSL
     IKRVFNVEVE ILVRKKMKLK KNNIYICRTK MKAKEILDEL GILKDGIFTH EIDHSMIQDD
     EMRRSYLRGA FLAGGSVNNP ETSSYHLEIF SQNESHAEGL TKLMNSYELN AKHLERKKGS
     ITYLKEAEKI SDFLSLIGGY QALLKFEDVR IVRDMRNSVN RLVNCETANL NKTVSAAMKQ
     VESIKLIDKE IGIENLPDRL REIARIRVEH QEISLKELGE MVSTGPISKS GVNHRLRKLN
     DLADKIRNGE QIEL