ID   CAN1N_EMENI             Reviewed;         339 AA.
AC   C8VP82; Q5BAG8;
DT   01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Cullin-associated NEDD8-dissociated protein 1, N-terminal part;
DE   AltName: Full=Cullin-associated and neddylation-dissociated protein 1, N-terminal part;
GN   Name=candA-N; ORFNames=AN2462;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND INTERACTION WITH CANDA-C;
RP   CULA AND CULD.
RX   PubMed=21119001; DOI=10.1091/mbc.e10-08-0732;
RA   Helmstaedt K., Schwier E.U., Christmann M., Nahlik K., Westermann M.,
RA   Harting R., Grond S., Busch S., Braus G.H.;
RT   "Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site
RT   mediates interaction to the neddylation site.";
RL   Mol. Biol. Cell 22:153-164(2011).
CC   -!- FUNCTION: Assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin
CC       ligase complexes that promotes the exchange of the substrate-
CC       recognition F-box subunit in SCF complexes, thereby playing a key role
CC       in the cellular repertoire of SCF complexes. Acts as a F-box protein
CC       exchange factor when interacting with candA-C (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with candA-C. Interacts with unneddylated cullins
CC       culA and culD; interaction occurs only when complexed with candA-C.
CC       {ECO:0000269|PubMed:21119001}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21119001}.
CC       Note=Requires candA-C for nuclear localization.
CC   -!- DISRUPTION PHENOTYPE: Cells show a dark red color when grown on an air-
CC       medium interface that induces development. Cells are able to initiate
CC       the cycle but are blocked in the initial stage of early nest formation.
CC       Cells exhibit reduction in asexual development and block in sexual
CC       development. {ECO:0000269|PubMed:21119001}.
CC   -!- MISCELLANEOUS: In E.nidulans, CAND1 is separated into 2 distinct
CC       proteins: candA-N and candA-C (AC Q5BAH2), corresponding to the N- and
CC       C-termini respectively of the protein in other species.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA64168.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AACD01000040; EAA64168.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001307; CBF86906.1; -; Genomic_DNA.
DR   RefSeq; XP_660066.1; XM_654974.1.
DR   AlphaFoldDB; C8VP82; -.
DR   SMR; C8VP82; -.
DR   STRING; 162425.CADANIAP00009179; -.
DR   EnsemblFungi; CBF86906; CBF86906; ANIA_10306.
DR   EnsemblFungi; EAA64168; EAA64168; AN2462.2.
DR   GeneID; 2875404; -.
DR   KEGG; ani:AN2462.2; -.
DR   VEuPathDB; FungiDB:AN10306; -.
DR   eggNOG; KOG1824; Eukaryota.
DR   HOGENOM; CLU_357759_0_0_1; -.
DR   InParanoid; C8VP82; -.
DR   OMA; MAIIQND; -.
DR   OrthoDB; 971352at2759; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IDA:AspGD.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0010265; P:SCF complex assembly; IBA:GO_Central.
DR   GO; GO:0043935; P:sexual sporulation resulting in formation of a cellular spore; IMP:AspGD.
DR   GO; GO:0000909; P:sporocarp development involved in sexual reproduction; IMP:AspGD.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039852; CAND1/CAND2.
DR   PANTHER; PTHR12696; PTHR12696; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..339
FT                   /note="Cullin-associated NEDD8-dissociated protein 1, N-
FT                   terminal part"
FT                   /id="PRO_0000422244"
FT   REPEAT          5..42
FT                   /note="HEAT 1"
FT   REPEAT          50..87
FT                   /note="HEAT 2"
SQ   SEQUENCE   339 AA;  36843 MW;  D448F2E0B453BAE1 CRC64;
     MGDRHTIQQN LNGLLSKLND PDPDMRYMSL NDLYGILSNP CSSYLAHDQA SATRLAEGLL
     KALDDQHGDV QNQALKCLGP LVARLPLEGL RTLLERLSNL TTSQTIDTSV PNTALRVIVT
     ALPRPQPNQA PSPDANMAYS AVSEVLIPRL IGPGPHKRRG SVTKGMLEKD PAKGFSSDAI
     DVLIQVASCF GALLQESELT ALEKAVMSII DNDTAGTVVT KRALAAISAL VVYFSDEQFG
     ILVSELVERF NSPQLSTVHR RHLIAAVGCL ARTVPAKFGP HLSTLAPFIF SAVGEDNLEV
     SHVLHYLCTS ASNVYSSRNK PKIYHQYRQL PKEKLITGM