ID   WHIA_STRPM              Reviewed;         303 AA.
AC   Q48UH3;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420}; OrderedLocusNames=M28_Spy0519;
OS   Streptococcus pyogenes serotype M28 (strain MGAS6180).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=319701;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS6180;
RX   PubMed=16088825; DOI=10.1086/430618;
RA   Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B.,
RA   Lefebvre R.B., Musser J.M.;
RT   "Genome sequence of a serotype M28 strain of group A Streptococcus:
RT   potential new insights into puerperal sepsis and bacterial disease
RT   specificity.";
RL   J. Infect. Dis. 192:760-770(2005).
CC   -!- FUNCTION: Involved in cell division and chromosome segregation.
CC       {ECO:0000255|HAMAP-Rule:MF_01420}.
CC   -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01420}.
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DR   EMBL; CP000056; AAX71633.1; -; Genomic_DNA.
DR   RefSeq; WP_002990485.1; NC_007296.2.
DR   AlphaFoldDB; Q48UH3; -.
DR   SMR; Q48UH3; -.
DR   EnsemblBacteria; AAX71633; AAX71633; M28_Spy0519.
DR   KEGG; spb:M28_Spy0519; -.
DR   HOGENOM; CLU_053282_0_0_9; -.
DR   OMA; CDAEAAW; -.
DR   Proteomes; UP000009292; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR   Gene3D; 3.10.28.10; -; 1.
DR   HAMAP; MF_01420; HTH_type_WhiA; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR   InterPro; IPR003802; Sporulation_regulator_WhiA.
DR   InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR   InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR   PANTHER; PTHR37307; PTHR37307; 1.
DR   Pfam; PF02650; HTH_WhiA; 1.
DR   Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR   Pfam; PF10298; WhiA_N; 1.
DR   SUPFAM; SSF55608; SSF55608; 1.
DR   TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA-binding.
FT   CHAIN           1..303
FT                   /note="Probable cell division protein WhiA"
FT                   /id="PRO_0000376587"
FT   DNA_BIND        272..303
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ   SEQUENCE   303 AA;  33901 MW;  CD23290FDF20AC99 CRC64;
     MSFTTKVKEE LIHLSTGDNN ELAAIIKLSG SLGLAHQSLH LSITTENAKI ARYIYSLIED
     AYVIVPEIRY HQKTNLRKNR VYTVYVEQGV ETILADLKLA DSFFGLETGI EPQVLSDDNA
     GRSYLKGAFL AAGSIRDPES GKYQLEIYSV YLDHAQDLAQ LMQKFMLDAK TIEHKSGAVT
     YVQKAEDIMD FLIIIGAMSC KEDFEAIKLL REARNDINRA NNAETANIAK TISASMKTIN
     NIIKIMDTIG LESLPIELQQ VAQLRVKHPD YSIQQVADAL EFPITKSGVN HRLRKINKIA
     DDL