ID   WHIA_STRPQ              Reviewed;         303 AA.
AC   P0DH43; Q79WN1; Q8K849;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420}; OrderedLocusNames=SPs1391;
OS   Streptococcus pyogenes serotype M3 (strain SSI-1).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=193567;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSI-1;
RX   PubMed=12799345; DOI=10.1101/gr.1096703;
RA   Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y.,
RA   Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H.,
RA   Hattori M., Hamada S.;
RT   "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-
RT   scale genomic rearrangement in invasive strains and new insights into phage
RT   evolution.";
RL   Genome Res. 13:1042-1055(2003).
CC   -!- FUNCTION: Involved in cell division and chromosome segregation.
CC       {ECO:0000255|HAMAP-Rule:MF_01420}.
CC   -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01420}.
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DR   EMBL; BA000034; BAC64486.1; -; Genomic_DNA.
DR   RefSeq; WP_011054317.1; NC_004606.1.
DR   AlphaFoldDB; P0DH43; -.
DR   SMR; P0DH43; -.
DR   GeneID; 57852350; -.
DR   KEGG; sps:SPs1391; -.
DR   HOGENOM; CLU_053282_0_0_9; -.
DR   OMA; CDAEAAW; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR   Gene3D; 3.10.28.10; -; 1.
DR   HAMAP; MF_01420; HTH_type_WhiA; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR   InterPro; IPR003802; Sporulation_regulator_WhiA.
DR   InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR   InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR   PANTHER; PTHR37307; PTHR37307; 1.
DR   Pfam; PF02650; HTH_WhiA; 1.
DR   Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR   Pfam; PF10298; WhiA_N; 1.
DR   SUPFAM; SSF55608; SSF55608; 1.
DR   TIGRFAMs; TIGR00647; DNA_bind_WhiA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA-binding.
FT   CHAIN           1..303
FT                   /note="Probable cell division protein WhiA"
FT                   /id="PRO_0000411661"
FT   DNA_BIND        272..303
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ   SEQUENCE   303 AA;  33949 MW;  6D2CCDF5DF20AFD5 CRC64;
     MSFTTKVKEE LIHLSTGDNN ELAAIIKLSG SLGLAHQSLH LSITTENAKI ARYIYSFIED
     AYVIVPEIRY HQKTNLRKNR VYTVYVEQGV ETILADLKLA DSFFGLETGI EPQVLSDDNA
     GRSYLKGAFL AAGSIRDPES GKYQLEIYSV YLDHAQDLAQ LMQKFMLDAK TIEHKSGAVT
     YLQKAEDIMD FLIIIGAMSC KEDFEAIKLL REARNDINRA NNAETANIAK TISASMKTIN
     NIIKIMDTIG LESLPIELQQ VAQLRVKHPD YSIQQVADAL EFPITKSGVN HRLRKINKIA
     DDL