ID   CAN1_CANAW              Reviewed;         571 AA.
AC   P43059;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Lysine/arginine permease;
DE   AltName: Full=Basic amino acids permease;
GN   Name=CAN1;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=7725800; DOI=10.1002/yea.320101214;
RA   Sychorova H., Souciet J.-L.;
RT   "CAN1, a gene encoding a permease for basic amino acids in Candida
RT   albicans.";
RL   Yeast 10:1647-1651(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: High-affinity permease for arginine and lysine.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. YAT (TC 2.A.3.10) family. {ECO:0000305}.
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DR   EMBL; X76689; CAA54122.1; -; Genomic_DNA.
DR   EMBL; CM000312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S50711; S50711.
DR   AlphaFoldDB; P43059; -.
DR   SMR; P43059; -.
DR   STRING; 5476.P43059; -.
DR   TCDB; 2.A.3.10.20; the amino acid-polyamine-organocation (apc) family.
DR   Proteomes; UP000001429; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004840; Amoino_acid_permease_CS.
DR   Pfam; PF00324; AA_permease; 1.
DR   PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..571
FT                   /note="Lysine/arginine permease"
FT                   /id="PRO_0000054149"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        504..524
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        20
FT                   /note="L -> S (in Ref. 1; CAA54122)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        275
FT                   /note="T -> S (in Ref. 1; CAA54122)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   571 AA;  63358 MW;  7049DB4E8172C9D6 CRC64;
     MPEDYEKYRM GSSNESHQKL VQPISSSISK SNKKTKHQTD FVQDSDIIEA SSINDEFGEV
     KRDLKARHVS MIAIGGTIGT GLFISTGSLL HTTGPVMSLI SFLFVTTICF SVTQSLGEMA
     TYIPISGSFA QFVTRWVSKS CGAANGWLYW FSWAVTFGLE LSVVGQVIQF WTDAVPLAAW
     ISIFFVILTI FNFFPVKFYG EVEFWIASIK IIAVFGWIIY AFIMVCGAGK TGPVGFRYWR
     NGYAWGDGIL VNNNGKYVAA FVSGLINSIF TFQGTELVAV TAGEASPRAL RSAIRKVMFR
     ILVFYVLCML FMGLLVPYND PKLTQDGGFT RNSPFLIAME NSGTKVLPHI FNAVIVTTII
     SAGNSNIYSG SRILYGLAQA GVAPKFFLRT NKGGVPFFAV AFTAAFGALG YLACSSQGNK
     AFTWLLNITA TAGLISWGFI SVSHIRFMKT LQRRGISRDT LPFKAFFMPF SAYYGMVVCF
     IVVLIQGFTV FWDFNASDFF TAYISVILFV VLWVGFHFFF YGFGKDSFKM SNILVPLDEC
     DIDSGVRDIN DAEFDIPPPK NAWDKFWANV A