ID   WHITE_ANOAL             Reviewed;         709 AA.
AC   Q16928;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Protein white;
GN   Name=W;
OS   Anopheles albimanus (New world malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7167;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Teco;
RX   PubMed=9465401; DOI=10.1023/a:1018376525897;
RA   Ke Z., Benedict M.Q., Cornel A.J., Besansky N.J., Collins F.H.;
RT   "The Anopheles albimanus white gene: molecular characterization of the gene
RT   and a spontaneous white gene mutation.";
RL   Genetica 101:87-96(1997).
CC   -!- FUNCTION: May be part of a membrane-spanning permease system necessary
CC       for the transport of pigment precursors into pigment cells responsible
CC       for eye color.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC       Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR   EMBL; L76302; AAA88240.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q16928; -.
DR   SMR; Q16928; -.
DR   STRING; 7167.Q16928; -.
DR   PRIDE; Q16928; -.
DR   VEuPathDB; VectorBase:AALB006905; -.
DR   VEuPathDB; VectorBase:AALB20_033802; -.
DR   Proteomes; UP000069272; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR043926; ABCG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005284; Pigment_permease/Abcg.
DR   Pfam; PF01061; ABC2_membrane; 1.
DR   Pfam; PF19055; ABC2_membrane_7; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00955; 3a01204; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Glycoprotein; Membrane; Nucleotide-binding; Pigment;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..709
FT                   /note="Protein white"
FT                   /id="PRO_0000093379"
FT   TRANSMEM        457..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        487..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        537..555
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        564..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        598..616
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        681..700
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          103..348
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         136..143
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         292..299
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   CARBOHYD        485
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        658
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   709 AA;  79052 MW;  FBD76D5C69D3BECA CRC64;
     MTINTDDQYA DGESKTTISS NRRYSTSSFQ DQSMEDDGIN ATLTNDKATL IQVWRPKSYG
     SVKGQIPAQD RLTYTWREID VFGQAAIDGK SREPLCSRLR HCFTRQRLVK DFNPRKHLLK
     NVTGVARSGE LLAVMGSSGA GKTTLLNELA FRSPPGVKIS PNAIRTLNGV PVTAEQMRAR
     CAYVQQDDLF IPSLTTKEHL MFQAMLRMGR DVPATPIKMH RVDEVLQELS LVKCADTIIG
     VAGRVKGLSG GERKRTAFRS ETLTDPHLLL CDEPTSSLDS FMAQSVLQVL KGMAMKGKTI
     ILTIHQPSSE LYCLFDRILL VAEGVAFLGS PYQSADFFSQ LGIPCPPNYN PADFYVQMLA
     IAPNKETECR ETIKKICDSF AVSPIARDII ETASQVNGDG GIELTRTKHT TDPYFLQPME
     GVDSTGYRAS WWTQFYCILW RSWLSVLKDP MLVKVRLLQT AMVASLIGSI YFGQVLDQDG
     VMNINGSLFL FLTNMTFQNV FAVINVFSAE LPVFLREKRS RLYRVDTYFL GKTIAELPLF
     IAVPFVFTSI TYPMIGLKAA ISHYLTTLFI VTLVANVSTS FGYLISCASS SISMALSVGP
     PVVIPFLIFG GFFLNSASVP AYFKYLSYLS WFRYANEALL INQWADHRDG EIGCTRANVT
     CPASGEIILE TFNFRVEDFA LDIGCLFALI VLFRLGALFC LWLRSRSKE