WHITE_ANOGA
ID WHITE_ANOGA Reviewed; 695 AA.
AC Q27256; Q17006; Q7PRY2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Protein white;
GN Name=w; ORFNames=AGAP000553;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=Suakoko / G3;
RX PubMed=8825759; DOI=10.1111/j.1365-2583.1995.tb00027.x;
RA Besansky N.J., Bedell J.A., Benedict M.Q., Mukabayire O., Hilfiker D.,
RA Collins F.H.;
RT "Cloning and characterization of the white gene from Anopheles gambiae.";
RL Insect Mol. Biol. 4:217-231(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: May be part of a membrane-spanning permease system necessary
CC for the transport of pigment precursors into pigment cells responsible
CC for eye color.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAA06417.4; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; U29484; AAC47423.1; -; Genomic_DNA.
DR EMBL; U29485; AAC46994.1; -; Genomic_DNA.
DR EMBL; U29486; AAC46995.1; -; mRNA.
DR EMBL; AAAB01008846; EAA06417.4; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_310530.3; XM_310530.3.
DR AlphaFoldDB; Q27256; -.
DR SMR; Q27256; -.
DR STRING; 7165.AGAP000553-PA; -.
DR PaxDb; Q27256; -.
DR GeneID; 1271671; -.
DR KEGG; aga:AgaP_AGAP000553; -.
DR CTD; 1271671; -.
DR VEuPathDB; VectorBase:AGAP000553; -.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_6_1; -.
DR InParanoid; Q27256; -.
DR OrthoDB; 1022017at2759; -.
DR Proteomes; UP000007062; Chromosome X.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005284; Pigment_permease/Abcg.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00955; 3a01204; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Glycoprotein; Membrane; Nucleotide-binding; Pigment;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..695
FT /note="Protein white"
FT /id="PRO_0000093380"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 524..544
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 669..689
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 96..344
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 133..140
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CARBOHYD 472
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 645
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 100
FT /note="N -> S (in Ref. 1; AAC47423)"
FT /evidence="ECO:0000305"
FT CONFLICT 691..693
FT /note="SRS -> YAR (in Ref. 1; AAC47423)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 695 AA; 77219 MW; EE8B9517239B2961 CRC64;
MTINTDDQYG DAESKTTISS SRRYSSSSYQ DQSMDDALNT TLTNDKATLI QVWKPKSYGS
VKGQIPQCER LTYTWKEIDV FGEAPTDGKP REPLCTRLRN CCTRQRKDFN PRKHLLKNVT
GVAKSGELLA VMGSSGAGKT TLLNALAFRS PPGVKISPNA VRALNGVPVN AEQLRARCAY
VQQDDLFIPS LTTREHLLFQ AMLRMGRDVP ASVKQHRVQE VLQELSLVKC ADTIIGAPGR
IKGLSGGERK RLAFASETLT DPHLLLCDEP TSGLDSFMAH SVLQVLKGMA MKGKTIILTI
HQPSSELYCL FDKILLVAEG RVAFLGSPYQ SAEFFSQLGI PCPPNYNPAD FYVQMLAIAP
AKEAECRDMI KKICDSFAVS PIAREVLETA SVAGKGMDEP YMLQQVEGVG STGYRSSWWT
QFYCILWRSW LSVLKDPMLV KVRLLQTAMV ATLIGSIYFG QVLDQDGVMN INGSLFLFLT
NMTFQNVFAV INVFSAELPV FLREKRSRLY RVDTYFLGKT IAELPLFIAV PFVFTSITYP
MIGLRTGATH YLTTLFIVTL VANVSTSFGY LISCASSSIS MALSVGPPVV IPFLIFGGFF
LNSASVPAYF KYLSYLSWFR YANEALLINQ WSTVVDGEIA CTRANVTCPR SEIILETFNF
RVEDFALDIA CLFALIVLFR LGALLCLWLR SRSKE
