ID   WHITE_CERCA             Reviewed;         679 AA.
AC   Q17320;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Protein white;
GN   Name=W;
OS   Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC   Tephritidae; Ceratitis; Ceratitis.
OX   NCBI_TaxID=7213;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8533095; DOI=10.1126/science.270.5244.2005;
RA   Zwiebel L.J., Saccone G., Zacharopoulou A., Besansky N.J., Favia G.,
RA   Collins F.H., Louis C., Kafatos F.C.;
RT   "The white gene of Ceratitis capitata: a phenotypic marker for germline
RT   transformation.";
RL   Science 270:2005-2007(1995).
CC   -!- FUNCTION: May be part of a membrane-spanning permease system necessary
CC       for the transport of pigment precursors into pigment cells responsible
CC       for eye color.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC       Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
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DR   EMBL; X89933; CAA61998.1; -; mRNA.
DR   RefSeq; NP_001266294.1; NM_001279365.1.
DR   AlphaFoldDB; Q17320; -.
DR   SMR; Q17320; -.
DR   GeneID; 101458180; -.
DR   KEGG; ccat:101458180; -.
DR   CTD; 31271; -.
DR   OrthoDB; 1022017at2759; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0031409; F:pigment binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR043926; ABCG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005284; Pigment_permease/Abcg.
DR   Pfam; PF01061; ABC2_membrane; 1.
DR   Pfam; PF19055; ABC2_membrane_7; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00955; 3a01204; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Membrane; Nucleotide-binding; Pigment;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..679
FT                   /note="Protein white"
FT                   /id="PRO_0000093381"
FT   TRANSMEM        427..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        507..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        534..555
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        568..586
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        651..670
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          84..332
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         121..128
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   CARBOHYD        628
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        643
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   679 AA;  75145 MW;  3F9CBC78A835C4CC CRC64;
     MGQEDQEVLI RGGKATSTSA ESLNNNNEQP YEQSSINQGF CKNYGTLSPP SPALTADNLT
     YSWYNLDVFG AVHQPGSSWK QLVNRVKGVF CNERHIPAPR KHLLKNDSGV AYPGELLAVM
     GSSGAGKTTL LNASAFRSSK GVQISPSTIR MLNGHPVDAK EMQARCAYVQ QDDLFIGSLT
     AREHLIFQAM VRMPRHMTQK QKVQRVDQVI QDLSLGKCQN TLIGVPGRVK GLSGGERKRL
     AFASEALTDP PLLICDEPTS GLDSFMAHSV VQVLKKLSQK GKTVILTIHQ PSSELFELFD
     KILLMAEGRV AFLGTPGEAV DFFSYIGATC PTNYTPADFY VQVLAVVPGR EVESRDRVAK
     ICDNFAVGKV SREMEQNFQK LVKSNGFGKE DENEYTYKAS WFMQFRAVLW RSWLSVLKEP
     LLVKVRLLQT TMVAVLIGLI FLGQQLTQVG VMNINGAIFL FLTNMTFQNS FATITVFTTE
     LPVFMRETRS RLYRCDTYFL GKTIAELPLF LVVPFLFTAI AYPLIGLRPG VDHFFTALAL
     VTLVANVSTS FGYLISCACS STSMALSVGP PVIIPFLLFG GFFLNSGSVP VYFKWLSYLS
     WFRYANEGLL INQWADVKPG EITCTLSNTT CPSSGEVILE TLNFSASDLP FDFIGLALLI
     VGFRISAYIA LTMRARRKE